Hewitson T, Kamitsuji H, Whitworth J A, Kincaid-Smith P
Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Clin Exp Hypertens A. 1988;10(4):649-66. doi: 10.3109/10641968809033916.
The aim of the present experiments was to determine if anticoagulant and antithrombotic drugs, which protect against hypertension and vascular damage in some models of hypertension, have a similar effect in DOCA-salt hypertension. Unilaterally nephrectomized rats received injections of deoxycorticosterone acetate (DOCA) and 1% saline to drink and were treated with either heparin, defibrotide, low molecular weight (LMW) heparin or vehicle (control) for five and a half weeks. At sacrifice heparin treated rats had decreased hematocrit (p less than 0.001) and prolonged APTT (p less than 0.001). LMW heparin and defibrotide groups did not differ from control animals in either hematocrit or APTT. The systolic blood pressure (SBP) of heparin treated rats at sacrifice was lower than control (p less than 0.05) but, there were no other differences in SBP throughout the course of the experiment. Renal morphology revealed a lower number of glomerular epithelial cell droplets in the heparin group (p less than 0.01) only. Vascular damage did not differ significantly between groups.
本实验的目的是确定抗凝和抗血栓药物在去氧皮质酮盐性高血压模型中是否具有类似的作用，这些药物在某些高血压模型中可预防高血压和血管损伤。单侧肾切除的大鼠接受醋酸去氧皮质酮（DOCA）注射并饮用1%盐水，并用肝素、去纤苷、低分子量（LMW）肝素或赋形剂（对照）治疗5.5周。处死时，肝素治疗组大鼠的血细胞比容降低（p<0.001），活化部分凝血活酶时间延长（p<0.001）。LMW肝素组和去纤苷组在血细胞比容或活化部分凝血活酶时间方面与对照动物无差异。处死时，肝素治疗组大鼠的收缩压（SBP）低于对照组（p<0.05），但在整个实验过程中SBP没有其他差异。肾脏形态学显示，仅肝素组的肾小球上皮细胞液滴数量较少（p<0.01）。各组之间的血管损伤无显著差异。
