Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
Aging (Albany NY). 2021 Apr 27;13(9):12641-12659. doi: 10.18632/aging.202939.
Features of the deaths caused by COPD (chronic obstructive pulmonary disease) in cancer patients remained a controversial issue. This study aimed to characterize the demographic characteristics and mortality rates of the deaths from COPD in patients with cancer. In total, 7,846,370 cancer patients aged 40 years or older in the United States were identified from the Surveillance, Epidemiology, and End Results database (1975-2016). Mortality rates and SMRs (standardized mortality ratios) adjusted by age, race, sex, and calendar year were calculated to investigate the risk of COPD deaths in cancer survivors and to compare it with the general population. A total of 119,228 COPD deaths in patients with cancer were recorded, with a mortality rate of 261.5/100,000 person-years, nearly two-fold that of the general population (SMR, 2.17; 95% CI [confidence interval], 2.16-2.18). The proportion of cancer survivors dying from COPD increased from 0.9% in 1975 to 3.4% in 2016. Patients with lung cancer had a higher overall risk (SMR, 9.23; 95% CI, 9.12-9.35) than those with extrapulmonary malignancies. Among all extrapulmonary sites, laryngeal (SMR, 5.54; 95% CI, 5.34-5.75) and esophageal cancers (SMR, 4.33; 95% CI, 4.04-4.63) had the highest SMR. The risk of death from COPD increased with follow-up time.
COPD（慢性阻塞性肺疾病）导致的癌症患者死亡的特征仍然是一个有争议的问题。本研究旨在描述癌症患者 COPD 死亡的人口统计学特征和死亡率。从美国监测、流行病学和最终结果数据库（1975-2016 年）中确定了年龄在 40 岁或以上的 7846370 名癌症患者。计算死亡率和按年龄、种族、性别和日历年份调整的 SMR（标准化死亡率比），以调查癌症幸存者中 COPD 死亡的风险，并将其与一般人群进行比较。在癌症患者中记录了 119228 例 COPD 死亡，死亡率为 261.5/100000 人年，几乎是一般人群的两倍（SMR，2.17；95%CI[置信区间]，2.16-2.18）。死于 COPD 的癌症幸存者的比例从 1975 年的 0.9%增加到 2016 年的 3.4%。与肺外恶性肿瘤相比，肺癌患者的总体风险更高（SMR，9.23；95%CI，9.12-9.35）。在所有肺外部位中，喉（SMR，5.54；95%CI，5.34-5.75）和食管（SMR，4.33；95%CI，4.04-4.63）癌症的 SMR 最高。随着随访时间的延长，死于 COPD 的风险增加。
