Kligman L H
Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Cutis. 1988 Jun;41(6):419-20.
The characteristics of chronologically aged skin should be differentiated from the features of photoaging, which is marked by yellowed, leathery, sagging, wrinkled, elastic skin, as well as underlying connective tissue damage and various benign, premalignant, and malignant neoplasms. Laboratory experiments with the hairless mouse exposed to varying doses of ultraviolet radiation have demonstrated the protective effects of sunscreens, the repair of ultraviolet damage when the skin is no longer bombarded by photons, and the enhancement of that repair by retinoids.
应将自然老化皮肤的特征与光老化的特征区分开来，光老化的特征是皮肤发黄、呈皮革状、松弛、起皱、缺乏弹性，以及潜在的结缔组织损伤和各种良性、癌前和恶性肿瘤。对无毛小鼠进行不同剂量紫外线辐射的实验室实验表明了防晒霜的保护作用、皮肤不再受到光子轰击时紫外线损伤的修复，以及维甲酸对这种修复的增强作用。
