评估不孕男性的血浆游离氨基酸水平。
Assessment of Blood Plasma Free-amino Acid Levels in Infertile Men.
机构信息
Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan
Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
出版信息
In Vivo. 2021 May-Jun;35(3):1843-1847. doi: 10.21873/invivo.12446.
BACKGROUND/AIM: The objective of this study was to investigate the significance of the blood levels of free amino acids (AAs) in infertile men.
PATIENTS AND METHODS
Ninety-three men who underwent examinations for infertility were included. The concentrations of 20 AAs were measured and compared in four groups (normospermia, obstructive azoospermia, oligozoospermia, non-obstructive azoospermia) based on semen analysis and clinical parameters.
RESULTS
When the 93 men were divided into normospermia, obstructive azoospermia, oligozoospermia, and non-obstructive azoospermia groups, no significant differences were found in the concentrations of the 20 AAs between them. We then compared 49 men diagnosed with normozoospermia or oligozoospermia according to the median sperm motility and morphology abnormalities rates (30% and 20%, respectively). Men with low motility rates had significantly lower levels of tryptophan and alanine, and men with high abnormal morphology rates had significantly lower levels of aspartate and glutamate.
CONCLUSION
AAs are probably involved in the pathogenesis of male infertility, particularly oligozoospermia.
背景/目的：本研究旨在探讨血游离氨基酸（AAs）水平在男性不育症中的意义。
患者与方法
共纳入 93 例行不孕检查的男性。根据精液分析和临床参数，将 20 种氨基酸的浓度在 4 组（正常精子症、梗阻性无精子症、少精子症、非梗阻性无精子症）中进行测量和比较。
结果
将 93 名男性分为正常精子症、梗阻性无精子症、少精子症和非梗阻性无精子症组时，各组之间 20 种 AA 的浓度无显著差异。然后，我们根据精子运动和形态异常率的中位数（分别为 30%和 20%）将 49 名被诊断为正常精子症或少精子症的男性进行比较。低运动率的男性色氨酸和丙氨酸水平显著降低，高异常形态率的男性天冬氨酸和谷氨酸水平显著降低。
结论
AA 可能参与男性不育症的发病机制，尤其是少精子症。
Zotero 插件