卡培他滨角膜副作用的自体血衍生血清滴眼液治疗。
Treatment of Capecitabine Corneal Side Effects With Autologous Blood-derived Serum Eye Drops.
机构信息
Ophthalmology Unit, NESMOS Department, "Sapienza" University of Rome, Rome, Italy;
Ophthalmology Unit, NESMOS Department, "Sapienza" University of Rome, Rome, Italy.
出版信息
In Vivo. 2021 May-Jun;35(3):1881-1884. doi: 10.21873/invivo.12451.
BACKGROUND/AIM: To describe the clinical progress and management of ocular side effects in a 35-year-old patient with metastatic breast cancer who underwent oral chemotherapy with capecitabine and lapatinib.
MATERIALS AND METHODS
Slit lamp evaluation revealed bilateral perikeratic hyperemia, perilimbal conjunctival edema associated with corneal marginal infiltrates and epithelial and anterior stromal defects in both eyes. Slit lamp examination, in vivo confocal microscopy and anterior-segment optical coherence tomography were highly suggestive for limbal stem cell deficiency. The decision to administer autologous blood- derived serum eye drops was made.
RESULTS
Following administration of autologous blood-derived serum eye drops, corneal marginal infiltrates, epithelial and stromal defects significantly regressed in both eyes after only 10 days. Chemotherapy was resumed and serum eye drops were prescribed simultaneously.
CONCLUSION
Autologous blood-derived serum eye drops may be an adequate therapeutic choice for bilateral corneal lesions detected as ocular side effects of capecitabine.
背景/目的：描述一名 35 岁转移性乳腺癌患者在接受卡培他滨和拉帕替尼口服化疗后的眼部副作用的临床进展和处理方法。
材料和方法
裂隙灯检查显示双眼周边角膜充血，周边角膜缘水肿伴角膜边缘浸润和上皮及前基质缺损。裂隙灯检查、共焦显微镜和眼前段光学相干断层扫描高度提示为角膜缘干细胞缺乏症。决定给予自体血衍生血清滴眼剂。
结果
在给予自体血衍生血清滴眼剂后，仅 10 天后，双眼的角膜边缘浸润、上皮和基质缺损明显消退。恢复化疗，并同时开具血清滴眼剂。
结论
对于卡培他滨引起的眼部副作用中发现的双侧角膜病变，自体血衍生血清滴眼剂可能是一种合适的治疗选择。
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