Lee Ji Su, Yang Ji Hoon, Park Hyunsun, Yoon Hyun-Sun, Cho Soyun
Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
Ann Dermatol. 2019 Dec;31(6):662-665. doi: 10.5021/ad.2019.31.6.662. Epub 2019 Oct 31.
Hair follicle nevus (HFN) is a rare, benign, follicular hamartoma that most frequently presents as a congenital nodule on the face. We experienced a rare case of HFN on the neck of a 14-year-old boy and performed a pilot immunohistochemical study with cytokeratin 19 (CK19) to compare the staining pattern of hair follicles in HFN and its differential diagnoses, accessory tragus, cervical chondrocutaneous branchial remnants (CCBR) and trichofolliculoma. With hematoxylin and eosin stain, HFN showed numerous tiny hair follicles in the dermis with several sebaceous and eccrine glands, and perifollicular fibrous thickening. With CK19 stain, some hair follicles in HFN and CCBR showed positive expression, a few hair follicles in accessory tragus showed weak expression, and no hair follicles in trichofolliculoma showed expression. The present report supports the view that HFN, accessory tragus and CCBR are within the same spectrum of hamartomas.
毛囊痣（HFN）是一种罕见的良性毛囊错构瘤，最常见的表现是面部先天性结节。我们遇到一例罕见的14岁男孩颈部毛囊痣病例，并进行了一项初步免疫组织化学研究，使用细胞角蛋白19（CK19）来比较毛囊痣及其鉴别诊断，副耳屏、颈部软骨皮肤鳃裂残余（CCBR）和毛发滤泡瘤中毛囊的染色模式。苏木精和伊红染色显示，毛囊痣在真皮内有许多微小毛囊，伴有一些皮脂腺和汗腺，以及毛囊周围纤维增厚。CK19染色显示，毛囊痣和CCBR中的一些毛囊呈阳性表达，副耳屏中的少数毛囊呈弱阳性表达，毛发滤泡瘤中的毛囊无表达。本报告支持毛囊痣、副耳屏和CCBR属于同一错构瘤谱系的观点。
