Zepeda-Najar Cesar, Lino-Silva Leonardo Saul, Chávez-Hernandez Jazmin D, Salcedo-Hernández Rosa A, Jimenez-Sánchez Johana P, Fernández-Sánchez Carlos E, Valdez-Aguilar Carlos D
Surgical Oncology Division, Hospital Angeles Tijuana, Mexico.
Surgical Pathology, Melanoma and Gastrointestinal Cancer Division, Instituto Nacional de Cancerologia de Mexico, Mexico.
Contemp Oncol (Pozn). 2021;25(1):23-27. doi: 10.5114/wo.2021.104799. Epub 2021 Mar 24.
Obesity has been linked with an increased incidence of melanoma; however, there are few data about its impact on melanoma prognosis. We aimed to determine if there is an association between body mass index (BMI) and overall survival (OS) in 707 patients with melanoma.
A retrospective study of 707 patients with melanoma collected consecutively from 2005 to 2015 with a diagnosis of melanoma, who were been diagnosed and treated in our institution and who had clinical follow-up was carried out. Survival analysis was performed comparing patients according to their BMI.
In a multivariate analysis, factors influencing the 5-year OS were a positive margin (HR = 3.475, 95% CI: 1.829-6.600), the clinical-stage (HR = 2.565, 95% CI: 2.020-3.257, per switch to the upper stage), ulceration (HR = 3.475, 95% CI: 1.829-6.600), and BMI (HR .905, = 0.018 for the overweight group; HR = 0.663, = 0.021 for obesity grade I).
Patients who had a BMI between 25 and 34.9 kg/m had better survival.
肥胖与黑色素瘤发病率增加有关；然而，关于其对黑色素瘤预后影响的数据很少。我们旨在确定707例黑色素瘤患者的体重指数（BMI）与总生存期（OS）之间是否存在关联。
对2005年至2015年连续收集的707例黑色素瘤患者进行回顾性研究，这些患者在我们机构被诊断为黑色素瘤并接受治疗且有临床随访。根据患者的BMI进行生存分析比较。
在多变量分析中，影响5年总生存期的因素包括切缘阳性（HR = 3.475，95%CI：1.829 - 6.600）、临床分期（HR = 2.565，95%CI：2.020 - 3.257，每升高一期）、溃疡（HR = 3.475，95%CI：1.829 - 6.600）以及BMI（超重组HR = 0.905，P = 0.018；I级肥胖组HR = 0.663，P = 0.021）。
BMI在25至34.9 kg/m之间的患者生存期更好。
