Otsuka-Maeda Saki, Mijiddorj Myangat Tselmeg, Kajihara Ikko, Sakamoto Ryoko, Yamada-Kanazawa Saori, Kanemaru Hisashi, Nishimura Yuki, Sawamura Soichiro, Makino Katsunari, Aoi Jun, Makino Takamitsu, Masuguchi Shinichi, Fukushima Satoshi, Ihn Hironobu
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Jpn J Clin Oncol. 2021 Jul 1;51(7):1176-1178. doi: 10.1093/jjco/hyab062.
Extramammary Paget's disease is a rare malignant tumor of the skin that occurs primarily in the genitocrural region. Although the prognosis of extramammary Paget's disease with distant metastasis is poor, an effective therapy has not been established. Because Janus kinase 2 has attracted attention as a therapeutic target in several cancers, we investigated the expression of the Janus kinase 2 protein and the relationship between its level of expression and clinical significance in 53 patients with extramammary Paget's disease in our hospital. Immunohistochemistry showed that most extramammary Paget's disease tissues were positive for Janus kinase 2 (50/53, 94.3%), and the immunostaining intensity of Janus kinase 2 was correlated with the degree of invasiveness, lymph node metastasis and distant metastasis. Based on these findings, Janus kinase 2 may be a promising therapeutic target in extramammary Paget's disease.
乳房外佩吉特病是一种罕见的皮肤恶性肿瘤，主要发生在泌尿生殖区。尽管伴有远处转移的乳房外佩吉特病预后较差，但尚未确立有效的治疗方法。由于Janus激酶2作为几种癌症的治疗靶点已受到关注，我们调查了我院53例乳房外佩吉特病患者中Janus激酶2蛋白的表达及其表达水平与临床意义之间的关系。免疫组织化学显示，大多数乳房外佩吉特病组织的Janus激酶2呈阳性（50/53，94.3%），且Janus激酶2的免疫染色强度与侵袭程度、淋巴结转移和远处转移相关。基于这些发现，Janus激酶2可能是乳房外佩吉特病一个有前景的治疗靶点。
