Department of Oncology, Affiliated Hospital of Guangdong Medical University, No. 27 South of Ren Min Road, Zhanjiang, 524200, Guangdong, China.
Invest New Drugs. 2021 Oct;39(5):1454-1455. doi: 10.1007/s10637-021-01124-3. Epub 2021 Apr 28.
Recently, we read a paper "Preclinical assessment of histone deacetylase inhibitor quisinostat as a therapeutic agent against esophageal squamous cell carcinoma" published in Investigational New Drugs. Quisinostat may be a promising drug candidate for the treatment of esophageal squamous cell carcinoma. However, some problems existing in the methods part of this paper are worthy of comment.
最近,我们阅读了一篇发表在《新药研究》上的题为“组蛋白去乙酰化酶抑制剂 quisinostat 治疗食管鳞癌的临床前评估”的论文。Quisinostat 可能是治疗食管鳞癌的一种很有前途的候选药物。然而,该论文方法部分存在的一些问题值得讨论。