Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, P. R. China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, P. R. China.
J Org Chem. 2021 May 21;86(10):7263-7270. doi: 10.1021/acs.joc.1c00267. Epub 2021 Apr 29.
Three pairs of enantiomeric sesquiterpenoids, (∓)-syringanoid A ( and ) and (±)-pinnatanoids A ( and ) and B ( and ), that represent an unprecedented 5/4/6 tricyclic backbone and a rare 6/7 bicyclic backbone, respectively, were isolated from the peeled stems of . The structures were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, a modified Mosher's method, and quantum chemical calculations. A plausible biotransformation pathway for - was proposed, and their cardiomyocyte-protective and anti-inflammatory activities were evaluated.
从脱皮的 茎中分离得到三对对映体倍半萜，（±）-syringanoid A（和）和（±）-pinnatanoids A（和）和 B（和），分别代表一个前所未有的 5/4/6 三环骨架和一个罕见的 6/7 双环骨架。通过广泛的光谱分析、单晶 X 射线衍射、改进的 Mosher 法和量子化学计算确定了它们的结构。提出了 - 的可能生物转化途径，并评估了它们对心肌细胞的保护和抗炎活性。
