Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Department of Obstetrics and Gynecology, School of Medicine, Dokkyo Medical University, Tochigi, Japan.
J Surg Oncol. 2021 Jul;124(1):106-114. doi: 10.1002/jso.26471. Epub 2021 Apr 29.
We aimed to evaluate the prevalence of pulmonary embolism (PE) before cancer therapies in patients with ovarian and endometrial cancers with enhanced computed tomography (CT) using D-dimer (DD), and determine the optimal cut-off level of DD.
Since 2009, we have performed preoperative venous thromboembolism (VTE) screening of patients with ovarian and endometrial cancer. For patients with DD levels of more than 1.0 μg/ml, enhanced CT images were obtained from the pulmonary apex to the foot to detect PE and deep venous thrombosis (DVT) simultaneously.
Among patients with ovarian cancer, 84 of 413 (20.3%) had VTEs (DVT alone, n = 31 [7.5%]; PE with or without DVT, n = 53 [12.8%]; PE alone, n = 12 [2.9%]). Among patients with endometrial cancer, 50 of 455 (11.0%) had VTEs (DVT alone, n = 19 [4.2%]; PE with or without DVT, n = 31 [6.8%], PE alone, n = 14 [3.1%]). The optimal cut-off level of DD was estimated to be ≥1.5 and ≥1.2 μg/ml in ovarian and endometrial cancers, respectively.
Our study revealed a high prevalence of PE before cancer therapies in patients with ovarian and endometrial cancers by enhanced CT using DD.
我们旨在评估使用 D-二聚体（DD）对卵巢癌和子宫内膜癌患者进行增强 CT 检查前癌症治疗前肺栓塞（PE）的患病率，并确定 DD 的最佳截断值。
自 2009 年以来，我们对卵巢癌和子宫内膜癌患者进行了术前静脉血栓栓塞症（VTE）筛查。对于 DD 水平超过 1.0μg/ml 的患者，从肺尖到足部进行增强 CT 图像以同时检测 PE 和深静脉血栓形成（DVT）。
在卵巢癌患者中，413 例中有 84 例（20.3%）患有 VTE（单纯 DVT，n=31[7.5%]；PE 伴或不伴 DVT，n=53[12.8%]；单纯 PE，n=12[2.9%]）。在子宫内膜癌患者中，455 例中有 50 例（11.0%）患有 VTE（单纯 DVT，n=19[4.2%]；PE 伴或不伴 DVT，n=31[6.8%]，单纯 PE，n=14[3.1%]）。DD 的最佳截断值估计分别为≥1.5μg/ml 和≥1.2μg/ml，用于卵巢癌和子宫内膜癌。
我们的研究通过使用 DD 进行增强 CT 显示，卵巢癌和子宫内膜癌患者在癌症治疗前存在高比例的 PE。
Zotero 插件