Hacioglu Mayram, Oyardi Ozlem, Kirinti Alpcan
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.
Z Naturforsch C J Biosci. 2021 Apr 29;76(11-12):443-450. doi: 10.1515/znc-2021-0002. Print 2021 Nov 25.
spp. can form biofilms on mucosal surfaces and epithelial cells as well as on devices implanted in the body such as catheters and dentures, which are thought to underlie the most recalcitrant infections. It was aimed to show antifungal and antibiofilm activities of oregano oil () The antifungal activities of some essential oils were investigated against spp. and among them, oregano oil was found to be the most effective oil and further biofilm studies were conducted with it. Oregano oil inhibited biofilm adhesion and formation of spp. and mature biofilms and also displayed the ability to reduce biofilm formation when they were allowed to form on surfaces previously coated with oil (up to 50% inhibition rates). In addition, oregano oil was found to be effective against dual biofilms of at different concentrations. This study suggests that essential oil has useful antibiofilm effects against spp. The inhibitory effects of essential oil, against spp., were demonstrated for the first time. It also had antifungal effect on biofilm formation and established biofilm even at MIC level.
某些物种可在粘膜表面、上皮细胞以及体内植入装置（如导管和假牙）上形成生物膜，这些被认为是最难治疗的感染的根源。本研究旨在展示牛至油的抗真菌和抗生物膜活性。研究了一些精油对某些物种的抗真菌活性，其中牛至油被发现是最有效的精油，并对其进行了进一步的生物膜研究。牛至油可抑制某些物种的生物膜粘附和形成以及成熟生物膜，并且当它们在预先涂有油的表面上形成时，牛至油还表现出减少生物膜形成的能力（抑制率高达50%）。此外，发现牛至油在不同浓度下对某些物种的双重生物膜有效。本研究表明，牛至精油对某些物种具有有益的抗生物膜作用。首次证明了牛至精油对某些物种的抑制作用。即使在最低抑菌浓度水平，它对生物膜形成和已形成的生物膜也具有抗真菌作用。
