锂离子对胃蛋白酶和胰蛋白酶体外活性的影响。
The influence of Li ions on pepsin and trypsin activity in vitro.
机构信息
Department of Clinical Psychology, Poznan University of Medical Sciences, Poland.
Department of Dietetics, Poznan University of Physical Education, Poland.
出版信息
J Trace Elem Med Biol. 2021 Jul;66:126763. doi: 10.1016/j.jtemb.2021.126763. Epub 2021 Apr 16.
BACKGROUND
The paper presents a study on the influence of different lithium carbonate and lithium citrate concentration on proteolytic enzymes, namely pepsin and trypsin, in vitro. Lithium can directly affect enzyme activity. Its influence on many bodily functions in both ill and healthy people has been proven.
METHODS
To assess the influence of Li ions concentration and the substrate/enzyme ratio on pepsin and trypsin activity in vitro, 60 factorial experiments were conducted (each repeated 30 times).
MAIN FINDINGS
For both enzymes, statistically significant changes in their activity under the influence of lihium carbonate and lithium citrate were observed. The biggest increase in enzyme activity reached even 198.6 % and the largest decrease in enzyme activity reached about 50 %.
CONCLUSIONS
The study shows that both organic and inorganic forms of lithium salts cause changes in the activity of digestive enzymes. Different concentrations of lithium carbonate and lithium citrate stimulate or inhibit the activity of trypsin and pepsin.
背景
本文研究了不同浓度的碳酸锂和柠檬锂对胃蛋白酶和胰蛋白酶这两种蛋白水解酶的体外影响。锂可以直接影响酶的活性，其对患病和健康人群的许多身体机能的影响已得到证实。
方法
为了评估锂离子浓度和底物/酶比对胃蛋白酶和胰蛋白酶体外活性的影响，进行了 60 个析因实验（每个实验重复 30 次）。
主要发现
对于这两种酶，都观察到了碳酸锂和柠檬锂影响下其活性的显著变化。酶活性的最大增幅甚至达到 198.6%，最大降幅约为 50%。
结论
该研究表明，有机和无机形式的锂盐都会导致消化酶活性的变化。不同浓度的碳酸锂和柠檬锂会刺激或抑制胰蛋白酶和胃蛋白酶的活性。
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