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兔实验性脂肪栓塞后的肺超微结构变化(作者译)

[Pulmonary ultrastructural changes following experimental fat embolism in the rabbit (author's transl)].

作者信息

Chomette G, Auriol M

出版信息

Pathol Biol (Paris). 1977 Oct;25(8):523-33.

PMID:339165
Abstract

The intravenous injection of triolein in the rabbit, besides general consequences in some viscera (functional ischemic necrosis of the right ventricle, systemic cerebral and kidney embolisms), induces in the lung non specific reactions similar to those observed after other pulmonary agressions. Yet, some peculiarities are observed only in this experimental model: severe and persistent septal oedema due to early endothelial changes; intensive inflammatory response with numerous macrophages. On the other hand, except in zones with epithelio-conjonctive repair process of necrotic foci, the epithelial reaction reduced to a temporary predominance of type 2-pneumonocytes, remains of low intensity.

摘要

给兔子静脉注射甘油三油酸酯,除了对某些内脏产生一般性影响(右心室功能性缺血坏死、全身性脑和肾栓塞)外,还会在肺部引发类似于其他肺部侵袭后观察到的非特异性反应。然而,只有在这个实验模型中才观察到一些特殊情况:由于早期内皮细胞变化导致严重且持续的间隔水肿;伴有大量巨噬细胞的强烈炎症反应。另一方面,除了在坏死灶上皮-结缔组织修复过程的区域外,上皮反应减弱为II型肺细胞的暂时优势,强度仍然较低。

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