金属和非甾体抗炎药对人红细胞δ-氨基-γ-酮戊酸脱水酶“体外”活性的影响（作者译）
[Influence of metals and non-steroid anti-inflammatory drugs on the activity of human red cell ALA dehydratase "in vitro" (author's transl)].
作者信息
Allain P, Premel-Cabic A
出版信息
Pathol Biol (Paris). 1977 Oct;25(8):535-40.
The effect of metals and drugs on the activity of human erythrocyte ALA dehydratase has been studied in vitro. The most inhibitory metals are with decreasing effect silver, copper, gold and selenium. Zinc, cadmium, mercury are inhibitory at high concentrations and activator at low concentrations. Arsenic, calcium, magnesium, manganese, potassium, cobalt have no effect. Within the drugs studied the non steroidal anti-inflammatory drugs (aspirin, keptoprofen, indometacin, phenylbutazone, sodium salicylate and niflumic acid) are the only group which inhibits the enzyme ALA dehydratase. This inhibition is suppressed by zinc. The non steroidal anti-inflammatory drugs can inhibit the activity of enzymes which need zinc for optimal activity.
已在体外研究了金属和药物对人红细胞δ-氨基-γ-酮戊酸脱水酶活性的影响。抑制作用最强的金属，按抑制作用递减顺序排列为银、铜、金和硒。锌、镉、汞在高浓度时具有抑制作用，而在低浓度时则为激活剂。砷、钙、镁、锰、钾、钴无影响。在所研究的药物中，非甾体抗炎药（阿司匹林、酮洛芬、吲哚美辛、保泰松、水杨酸钠和尼氟酸）是唯一能抑制δ-氨基-γ-酮戊酸脱水酶的药物组。这种抑制作用可被锌抑制。非甾体抗炎药可抑制那些需要锌来实现最佳活性的酶的活性。
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