Gimenez-Perez Gabriel, Franch-Nadal Josep, Ortega Emilio, Mata-Cases Manel, Goday Albert, Real Jordi, Rodriguez Angel, Vlacho Bogdan, Mauricio Dídac
Endocrinology Unit, Department of Medicine, Hospital General de Granollers, 08402 Granollers, Spain.
DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain.
J Clin Med. 2021 Apr 6;10(7):1536. doi: 10.3390/jcm10071536.
This study aims to evaluate the clinical characteristics, complications, degree of glycemic control, and cardiovascular risk factor control in patients with type 1 diabetes in Catalonia (Northwest of Spain).
Cross-sectional study using a database including clinical, laboratory, and treatment data. Patients with an ICD10 diagnosis of type 1 diabetes were included, excluding those treated with glucose-lowering agents other than insulin, or treated only with basal insulin two years after diagnosis.
15,008 patients were analysed. Median IQR age was 42 (31-53) years, diabetes duration 11.8 (6.8-16.0) years, 56.5% men. Median (IQR) HbA1c was 7.9% (7.1-8.8). Microvascular complications were present in 24.4% of patients, 43.6% in those with a diabetes duration >19 years. In presence of known cardiovascular disease 69.3% of patients showed an LDL-C concentration >70 mg/dL, 37% had a systolic blood pressure >135 mmHg and 22.4% were smokers.
This study provides a reliable snapshot about the clinical situation of a large population of patients with T1D in Catalonia, which is similar to that of other western areas. The lack of adequate control of cardiovascular risk factors in a significant proportion of patients with cardiovascular disease deserves a more detailed analysis and urges the need for improvement strategies.
本研究旨在评估西班牙西北部加泰罗尼亚地区1型糖尿病患者的临床特征、并发症、血糖控制程度以及心血管危险因素控制情况。
采用横断面研究，使用包含临床、实验室和治疗数据的数据库。纳入ICD10诊断为1型糖尿病的患者，排除诊断两年后使用除胰岛素以外的降糖药物治疗或仅使用基础胰岛素治疗的患者。
分析了15,008例患者。年龄中位数（四分位间距）为42（31 - 53）岁，糖尿病病程为11.8（6.8 - 16.0）年，男性占56.5%。糖化血红蛋白（HbA1c）中位数（四分位间距）为7.9%（7.1 - 8.8）。24.4%的患者存在微血管并发症，糖尿病病程>19年的患者中这一比例为43.6%。在已知患有心血管疾病的患者中，69.3%的患者低密度脂蛋白胆固醇（LDL-C）浓度>70mg/dL，37%的患者收缩压>135mmHg，22.4%的患者吸烟。
本研究提供了加泰罗尼亚地区大量1型糖尿病患者临床状况的可靠概况，与其他西部地区相似。相当一部分心血管疾病患者的心血管危险因素缺乏充分控制，值得进行更详细的分析，并迫切需要改进策略。
