用于测定片剂中保泰松和羟基保泰松的质子磁共振波谱法。
Proton magnetic resonance spectroscopic method for determination of phenylbutazone and oxyphenbutazone in tablets.
作者信息
Husain S, Kifayatullah M, Rao R N
机构信息
Regional Research Laboratory, Analytical Division, Hyderabad, India.
出版信息
J Assoc Off Anal Chem. 1988 May-Jun;71(3):525-7.
A simple, specific, and rapid 1H nuclear magnetic resonance spectroscopic method for the assay of phenylbutazone and oxyphenbutazone is described. Spectra are recorded in CDCI3 containing 1,3-dichloro-5-nitrobenzene as an internal standard. The aromatic proton resonances for the standard, at delta 7.7 and 8.2, are well separated from those of phenylbutazone and oxyphenbutazone, which are in the region of delta 6.5-7.3 ppm. Average percent recoveries of phenylbutazone and oxyphenbutazone were 98.9 and 98.6 with standard deviations of 0.6 and 0.7, respectively. Commercial formulations were analyzed and the results obtained by the proposed method closely agreed with those found by the British Pharmacopoeia method.
描述了一种用于测定保泰松和羟基保泰松的简单、特异且快速的氢核磁共振光谱法。光谱在含有1,3 - 二氯 - 5 - 硝基苯作为内标的氘代氯仿中记录。内标的芳族质子共振峰位于δ 7.7和8.2处，与保泰松和羟基保泰松的共振峰（位于δ 6.5 - 7.3 ppm区域）分得很开。保泰松和羟基保泰松的平均回收率分别为98.9%和98.6%，标准偏差分别为0.6和0.7。对市售制剂进行了分析，所提出方法得到的结果与英国药典方法得到的结果非常一致。
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