Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Center for Integrative Neuroscience and Inflammatory Diseases, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Cells. 2021 Apr 14;10(4):890. doi: 10.3390/cells10040890.
Pericytes are increasingly recognized as being important in the control of blood-brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and nomenclature of pericytes and other perivascular cell types. In addition, pericyte heterogeneity and mouse-human species differences have contributed to confusion. Herein we summarize our present knowledge on the identification of pericytes and pericyte subsets in humans, primarily focusing on recent findings in humans and nonhuman primates. Precise identification and definition of pericytes and pericyte subsets in humans may help us to better understand pericyte biology and develop new therapeutic approaches specifically targeting disease-associated pericyte subsets.
周细胞越来越被认为在控制血脑屏障通透性和血管血流方面起着重要作用。对这种重要细胞类型的研究受到广泛的困惑，这些困惑主要涉及周细胞和其他血管周围细胞类型的表型特征和命名。此外，周细胞的异质性和小鼠与人类之间的物种差异也导致了混淆。在此，我们总结了目前我们对人类周细胞和周细胞亚群的鉴定知识，主要侧重于人类和非人类灵长类动物的最新发现。精确鉴定和定义人类的周细胞和周细胞亚群可能有助于我们更好地理解周细胞生物学，并开发专门针对与疾病相关的周细胞亚群的新的治疗方法。
