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地中海饮食依从性与唾液成分的关系。

Relationship between Mediterranean Diet Adherence and Saliva Composition.

机构信息

MED (Mediterranean Institute for Agriculture, Environment and Development), Institute for Advanced Studies and Research (IIFA) IIFA-Instituto de Investigação e Formação Avançada, University of Évora, 7002-556 Évora, Portugal.

Department of Biology, University of Évora, 7002-556 Évora, Portugal.

出版信息

Nutrients. 2021 Apr 10;13(4):1246. doi: 10.3390/nu13041246.

DOI:10.3390/nu13041246
PMID:33920127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8068872/
Abstract

Dietary polyphenol exposure is known to change protein saliva composition in rodents, but less is known in humans. The present study aimed to assess the relationship between saliva protein composition and adherence to Mediterranean Diet (MD) and polyphenol intake levels. Participants were assessed for their dietary habits, which were converted in Mediterranean adherence level, according to Mediterranean Diet Adherence Score (MEDAS) score. Total polyphenol and total flavanol intakes were extrapolated from dietary data, using Phenol explorer database. Whole saliva was collected, and proteins were separated by SDS-PAGE. Salivary S-type cystatins were highly expressed in the group with medium adherence to MD, being positively correlated with wine intake in overweight individuals. The association between salivary amylase and MD adherence also depended on Body Mass Index (BMI), with a positive association only in normal weight individuals. Polyphenol intake was positively associated with S-type cystatins levels, particularly when flavanols were considered separately. These results show that saliva relationship with MD adherence depend on BMI, suggesting that normal weight and overweight individuals may have different salivary responses to diet. Moreover, these results reinforce the link between saliva and dietary polyphenols (flavanols) levels, leading to the hypothesis that salivary proteome can have a role in polyphenol-rich foods acceptance.

摘要

饮食多酚暴露已知会改变啮齿动物唾液中的蛋白质组成，但在人类中知之甚少。本研究旨在评估唾液蛋白组成与地中海饮食（MD）依从性和多酚摄入量之间的关系。评估参与者的饮食习惯，根据地中海饮食依从性评分（MEDAS）将其转化为地中海饮食依从性水平。使用 Phenol explorer 数据库从饮食数据中推断出总多酚和总黄烷醇的摄入量。收集全唾液，并通过 SDS-PAGE 分离蛋白质。唾液 S 型半胱氨酸蛋白酶抑制剂在中高度依从 MD 的组中高度表达，与超重个体的饮酒量呈正相关。唾液淀粉酶与 MD 依从性之间的关联也取决于体重指数（BMI），仅在正常体重个体中呈正相关。多酚摄入量与 S 型半胱氨酸蛋白酶抑制剂水平呈正相关，特别是当单独考虑黄烷醇时。这些结果表明，唾液与 MD 依从性的关系取决于 BMI，这表明正常体重和超重个体的饮食可能会对唾液产生不同的反应。此外，这些结果加强了唾液与膳食多酚（黄烷醇）水平之间的联系，从而提出了唾液蛋白质组可能在富含多酚的食物接受中发挥作用的假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/d4a60725a542/nutrients-13-01246-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/d1f4bf8dad75/nutrients-13-01246-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/39c0f826857e/nutrients-13-01246-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/e9b50a1e1a26/nutrients-13-01246-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/a7db9ffe9ac5/nutrients-13-01246-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/d4a60725a542/nutrients-13-01246-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/d1f4bf8dad75/nutrients-13-01246-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/39c0f826857e/nutrients-13-01246-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/e9b50a1e1a26/nutrients-13-01246-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/a7db9ffe9ac5/nutrients-13-01246-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/8068872/d4a60725a542/nutrients-13-01246-g005.jpg

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本文引用的文献

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Nutrients. 2020 Jul 16;12(7):2114. doi: 10.3390/nu12072114.
2
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Physiol Behav. 2020 Oct 15;225:113080. doi: 10.1016/j.physbeh.2020.113080. Epub 2020 Jul 15.
3
Validation of the Telephone-Administered Version of the Mediterranean Diet Adherence Screener (MEDAS) Questionnaire.
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