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儿科心脏病学临床研究的统计学处理

Statistical Treatment of Clinical Investigations in Pediatric Cardiology.

作者信息

Rao P Syamasundar

机构信息

University of Texas-Houston McGovern Medical School, Children's Memorial Hermann Hospital, Houston, TX 77030, USA.

出版信息

Children (Basel). 2021 Apr 12;8(4):296. doi: 10.3390/children8040296.

DOI:10.3390/children8040296
PMID:33921399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8069261/
Abstract

This paper describes various statistical methods used by the author during multiple studies conducted by the author. Initially, the data were scrutinized to ensure normal distribution, and expressed as mean ± standard deviation (SD) or standard error of mean (SEM) for normally distributed variables. Medians and ranges were given for the data with skewed distribution. Two tailed, paired tests or independent sample tests (analysis of variance) were used for normally distributed data, while non-parametric chi-square or similar other tests were utilized for data with skewed distribution. Statistical significance was set at a value of < 0.05. Bonferroni correction was applied when the study involves multiple comparisons. A number of other statistical methods used during these studies were also discussed. Finally, special methods used in evaluating aortic remodeling subsequent to balloon angioplasty of native aortic coarctation were reviewed.

摘要

本文描述了作者在多项研究中使用的各种统计方法。最初,对数据进行仔细检查以确保正态分布,对于呈正态分布的变量,以均值±标准差(SD)或均值标准误(SEM)表示。对于分布呈偏态的数据,给出中位数和范围。对于正态分布的数据,使用双侧配对t检验或独立样本t检验(方差分析),而对于分布呈偏态的数据,则使用非参数卡方检验或类似的其他检验。统计学显著性设定为P值<0.05。当研究涉及多次比较时,应用Bonferroni校正。还讨论了这些研究中使用的许多其他统计方法。最后,回顾了在评估原发性主动脉缩窄球囊血管成形术后主动脉重塑时使用的特殊方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e493/8069261/ac1a54475d3a/children-08-00296-g017.jpg
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