舌淋巴结转移作为口腔鳞状细胞癌的预后因素——一项回顾性多中心研究
Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma-A Retrospective Multicenter Study.
作者信息
Kikuchi Masahiro, Harada Hiroyuki, Asato Ryo, Hamaguchi Kiyomi, Tamaki Hisanobu, Mizuta Masanobu, Hori Ryusuke, Kojima Tsuyoshi, Honda Keigo, Tsujimura Takashi, Kumabe Yohei, Ichimaru Kazuyuki, Kitani Yoshiharu, Ushiro Koji, Kitamura Morimasa, Shinohara Shogo, Omori Koichi
机构信息
Department of Otolaryngology-Head & Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Department of Otolaryngology-Head & Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka 530-8480, Japan.
出版信息
Medicina (Kaunas). 2021 Apr 12;57(4):374. doi: 10.3390/medicina57040374.
The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analysis. LLN metastasis was noted in 67 patients (7.1%). Habitual alcohol consumption and clinical neck node metastasis were independent risk factors for LLN metastasis. LLN metastasis was an independent prognostic factor for disease-free and overall survival, although LLN dissection did not improve survival outcomes. LLN metastasis is an independent adverse prognostic factor. Further prospective studies are needed to fully assess the extent of LLN dissection required in OSCC patients.
舌淋巴结（LLN）转移在口腔鳞状细胞癌（OSCC）患者中的流行病学及预后作用仍不明确。在此，我们旨在分析OSCC患者中LLN转移的临床病理特征、危险因素及预后作用。总共对945例OSCC患者进行了回顾性分析。比较了有和没有LLN转移患者的临床病理特征。使用多变量分析评估LLN转移的危险因素及其对生存结果的影响。67例患者（7.1%）出现LLN转移。习惯性饮酒和临床颈部淋巴结转移是LLN转移的独立危险因素。尽管LLN清扫术并未改善生存结果，但LLN转移是无病生存和总生存的独立预后因素。LLN转移是一个独立的不良预后因素。需要进一步的前瞻性研究来全面评估OSCC患者所需的LLN清扫范围。
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