Belgorosky A, Rivarola M A
Centro de Investigaciones Endocrinologicas, Hospital de Ninos, Buenos Aires, Argentina.
J Clin Endocrinol Metab. 1988 Aug;67(2):234-7. doi: 10.1210/jcem-67-2-234.
We previously reported that serum sex hormone-binding globulin (SHBG) decreases and serum non-SHBG-bound testosterone (T) increases with age in normal prepubertal boys from infancy to late prepuberty. In this study we measured serum SHBG, T, estradiol (E2), and dehydroepiandrosterone sulfate (DS), and we calculated serum non-SHBG-bound T and E2 and free T and E2 in 22 normal prepubertal girls, aged 1-9.4 yr. The girls were divided into 3 groups of different ages: group A, 1.7 +/- 1.0 (mean +/- SE) yr; group B, 4.6 +/- 0.8 yr; and group C, 7.3 +/- 0.8 yr. In group C, mean serum SHBG level was lower, and serum T, non-SHBG-bound T, free T, DS, total E2, non-SHBG-bound E2, and free E2 were higher than in group A or B. Furthermore, a negative correlation was found between serum SHBG and age [y(nmol/L) = 144 - 9.07 x (yr); r = 0.57; P less than 0.001], while positive correlations were found between non-SHBG-bound T and age [y(nmol/L = 0.043 + 0.023 x (yr); r = 0.68; P less than 0.001], non-SHBG-bound E2 and age [y(pmol/L) = 0.69 + 2.82 x (yr); r = 0.6; P less than 0.001], and DS and age [y(nmol/L) = 25.2 + 63.8 x (yr); r = 0.59, P less than 0.001]. In a group of 19 normal age-matched prepubertal boys, we also found a significant correlation between non-SHBG-bound E2 and age. Since non-SHBG-bound sex hormone levels are good indicators of tissue available sex hormones, we conclude that in prepubertal girls, there is a progressive increase in the exposure of peripheral tissues to T and E2 with advancing age. Since sex hormones enhance tissue maturation, these increments might play a role in the somatic and psychic development of girls before the onset of the clinical signs of puberty.
我们之前报道过，从婴儿期到青春期后期的正常青春期前男孩，血清性激素结合球蛋白（SHBG）会随着年龄增长而降低，血清非SHBG结合睾酮（T）会随着年龄增长而升高。在本研究中，我们测量了22名年龄在1至9.4岁的正常青春期前女孩的血清SHBG、T、雌二醇（E2）和硫酸脱氢表雄酮（DS），并计算了血清非SHBG结合T和E2以及游离T和E2。这些女孩被分为3个不同年龄组：A组，1.7±1.0（均值±标准误）岁；B组，4.6±0.8岁；C组，7.3±0.8岁。在C组中，血清SHBG平均水平较低，而血清T、非SHBG结合T、游离T、DS、总E2、非SHBG结合E2和游离E2均高于A组或B组。此外，发现血清SHBG与年龄之间存在负相关[y（nmol/L）=144 - 9.07x（岁）；r = 0.57；P<0.001]，而非SHBG结合T与年龄之间存在正相关[y（nmol/L）=0.043 + 0.023x（岁）；r = 0.68；P<0.001]，非SHBG结合E2与年龄之间存在正相关[y（pmol/L）=0.69 + 2.82x（岁）；r = 0.6；P<0.001]，DS与年龄之间存在正相关[y（nmol/L）=25.2 + 63.8x（岁）；r = 0.59，P<0.001]。在一组19名年龄匹配的正常青春期前男孩中，我们还发现非SHBG结合E2与年龄之间存在显著相关性。由于非SHBG结合性激素水平是组织可利用性激素的良好指标，我们得出结论，在青春期前女孩中，随着年龄增长，外周组织暴露于T和E2的程度会逐渐增加。由于性激素会促进组织成熟，这些增加可能在青春期临床症状出现之前女孩的躯体和心理发育中发挥作用。
