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用于口咽吞咽困难的实验性损伤啮齿动物模型

Experimental Injury Rodent Models for Oropharyngeal Dysphagia.

作者信息

Kim Ji-Youn

机构信息

Department of Dental Hygiene, College of Health Science, Gachon University, Incheon 21936, Korea.

出版信息

Biology (Basel). 2021 Apr 23;10(5):360. doi: 10.3390/biology10050360.

Abstract

Oropharyngeal dysphagia is a disorder that can make swallowing difficult and reduce the quality of life. Recently, the number of patients with swallowing difficulty has been increasing; however, no comprehensive treatment for such patients has been developed. Various experimental animal models that mimic oropharyngeal dysphagia have been developed to identify appropriate treatments. This review aims to summarize the experimentally induced oropharyngeal dysphagia rodent models that can be used to provide a pathological basis for dysphagia. The selected studies were classified into those reporting dysphagia rodent models showing lingual paralysis by hypoglossal nerve injury, facial muscle paralysis by facial nerve injury, laryngeal paralysis by laryngeal and vagus nerve injury, and tongue dysfunction by irradiation of the head and neck regions. The animals used in each injury model, the injury method that induced dysphagia, the screening method for dysphagia, and the results are summarized. The use of appropriate animal models of dysphagia may provide adequate answers to biological questions. This review can help in selecting a dysphagia animal system tailored for the purpose of providing a possible solution to overcome dysphagia.

摘要

口咽吞咽困难是一种会导致吞咽困难并降低生活质量的病症。近来,吞咽困难患者的数量一直在增加;然而,尚未开发出针对此类患者的综合治疗方法。为了确定合适的治疗方法,已经开发出了各种模拟口咽吞咽困难的实验动物模型。本综述旨在总结可用于为吞咽困难提供病理基础的实验性诱导口咽吞咽困难啮齿动物模型。所选研究被分为以下几类:报告通过舌下神经损伤导致舌麻痹、通过面神经损伤导致面部肌肉麻痹、通过喉和迷走神经损伤导致喉麻痹以及通过头颈部区域照射导致舌功能障碍的吞咽困难啮齿动物模型。总结了每种损伤模型中使用的动物、导致吞咽困难的损伤方法、吞咽困难的筛查方法以及结果。使用合适的吞咽困难动物模型可能会为生物学问题提供充分的答案。本综述有助于选择一种为克服吞咽困难提供可能解决方案而量身定制的吞咽困难动物系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/8146227/d9f865869252/biology-10-00360-g001.jpg

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