Schmitt C, Kadish A H, Balke W C, Turk K, Buxton A E, Josephson M E, Marchlinski F E
Clinical Electrophysiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104.
J Am Coll Cardiol. 1988 Aug;12(2):395-403. doi: 10.1016/0735-1097(88)90412-3.
The effect of procainamide (mean concentration 9.1 +/- 2.0 micrograms/ml) on cycle length-dependent changes in electrographic characteristics was determined in 10 patients with prior myocardial infarction. Intracardiac bipolar electrograms were recorded from an abnormal left ventricular site in the distribution of prior (greater than 6 month) myocardial infarction and from a normal right ventricular site. Pacing was performed for 15 beats from the right ventricular apex at cycle lengths of 600 (or 500), 400 and 300 ms. In the control state, the QRS width, the normal electrogram and in 9 of the 10 patients the abnormal electrogram did not change with decreasing cycle lengths. After procainamide the mean QRS width increased from 203 +/- 32 to 240 +/- 50 ms (+18%, p less than 0.01) at a paced cycle length of 600 (or 500) ms, from 198 +/- 34 to 245 +/- 59 ms (+24%, p less than 0.01) at a paced cycle length of 400 ms and from 197 +/- 36 to 258 +/- 67 ms (+31%, p less than 0.01) at a paced cycle length of 300 ms.(ABSTRACT TRUNCATED AT 250 WORDS)
在10例有陈旧性心肌梗死的患者中，测定了普鲁卡因胺（平均浓度9.1±2.0微克/毫升）对心电图特征的周期长度依赖性变化的影响。从陈旧性（大于6个月）心肌梗死区域的异常左心室部位和正常右心室部位记录心腔内双极电图。在600（或500）、400和300毫秒的周期长度下，从右心室心尖起搏15次。在对照状态下，10例患者中有9例的QRS波宽度、正常心电图以及异常心电图不会随着周期长度的缩短而改变。给予普鲁卡因胺后，在600（或500）毫秒的起搏周期长度下，平均QRS波宽度从203±32毫秒增加到240±50毫秒（增加18%，p<0.01）；在400毫秒的起搏周期长度下，从198±34毫秒增加到245±59毫秒（增加24%，p<0.01）；在300毫秒的起搏周期长度下，从197±36毫秒增加到258±67毫秒（增加31%，p<0.01）。（摘要截断于250字）
