Saito J, Okamura K, Akagi K, Tanigawara S, Shintaku Y, Watanabe T, Akiyama N, Endo C, Sato A, Yajima A
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Jun;40(6):775-80.
In order to investigate changes in FHR when a fetus suffers acidemia, we produced progressively advanced acidemia in lamb fetus by intermittently repeated cord compression. FHR was monitored throughout the study. FHR patterns were classified into five characteristic types as fetal arterial pH fell from around 7.35 to below 6.90. It was confirmed by studies involving catecholamine release and the administration of drugs such as atropine sulfate, alpha or beta adrenergic antagonists that sympathetic and parasympathetic regulation was deeply involved in the changes. Among the patterns, type 4, in which decreased amplitude of the initial drop and hypoxia-induced deceleration was followed by overshoot acceleration, took place during acidemia at arterial pH below 7.15. In conclusion, the appearance of type 4 FHR indicates a deteriorating state in human fetus as well, induced by repeated cord compression, and obliges us to deliver the fetus as soon as possible.
为了研究胎儿发生酸血症时胎心率（FHR）的变化，我们通过间歇性重复脐带压迫，使羔羊胎儿逐渐发展为严重酸血症。在整个研究过程中监测胎心率。随着胎儿动脉血pH值从约7.35降至6.90以下，胎心率模式被分为五种特征类型。涉及儿茶酚胺释放以及硫酸阿托品、α或β肾上腺素能拮抗剂等药物给药的研究证实，交感神经和副交感神经调节与这些变化密切相关。在这些模式中，模式4（初始下降幅度减小和缺氧诱导的减速后出现过冲加速）发生在动脉血pH值低于7.15的酸血症期间。总之，模式4胎心率的出现表明，在人类胎儿中，反复脐带压迫也会导致胎儿状态恶化，这迫使我们尽快分娩胎儿。
