Estévez-López Fernando, Salazar-Tortosa Diego F, Camiletti-Moirón Daniel, Gavilán-Carrera Blanca, Aparicio Virginia A, Acosta-Manzano Pedro, Segura-Jiménez Víctor, Álvarez-Gallardo Inmaculada C, Carbonell-Baeza Ana, Munguía-Izquierdo Diego, Geenen Rinie, Lacerda Eliana, Delgado-Fernández Manuel, Martínez-González Luis J, Ruiz Jonatan R, Álvarez-Cubero María J
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85719, USA.
J Clin Med. 2021 Apr 28;10(9):1902. doi: 10.3390/jcm10091902.
Fatigue is a cardinal symptom in fibromyalgia. Fatigue is assumed to be the result of genetic susceptibility and environmental factors. We aimed at examining the role of genetic susceptibility for fatigue in southern Spanish women with fibromyalgia, by looking at single nucleotide polymorphisms in 34 fibromyalgia candidate-genes, at the interactions between genes, and at the gene-physical activity interactions. We extracted DNA from saliva of 276 fibromyalgia women to analyze gene-polymorphisms. Accelerometers registered physical activity and sedentary behavior. Fatigue was assessed with the Multidimensional Fatigue Inventory. Based on the Bonferroni's and False Discovery Rate values, we found that the genotype of the rs4453709 polymorphism (sodium channel protein type 9 subunit alpha, , gene) was related to reduced motivation (AT carriers showed the highest reduced motivation) and reduced activity (AA carriers showed the lowest reduced activity). Carriers of the heterozygous genotype of the rs1801133 (methylene tetrahydrofolate reductase, , gene) or rs4597545 ( gene) polymorphisms who were physically active reported lower scores on fatigue compared to their inactive counterparts. Highly sedentary carriers of the homozygous genotype of the rs7607967 polymorphism (AA/GG genotype; gene) presented more reduced activity (a dimension of fatigue) than those with lower levels of sedentary behavior. Collectively, findings from the present study suggest that the contribution of genetics and gene-physical activity interaction to fatigue in fibromyalgia is modest.
疲劳是纤维肌痛的主要症状。疲劳被认为是遗传易感性和环境因素共同作用的结果。我们旨在通过研究34个纤维肌痛候选基因中的单核苷酸多态性、基因间的相互作用以及基因与体力活动的相互作用，来探讨西班牙南部纤维肌痛女性中遗传易感性对疲劳的作用。我们从276名纤维肌痛女性的唾液中提取DNA，以分析基因多态性。加速度计记录体力活动和久坐行为。使用多维疲劳量表评估疲劳程度。基于邦费罗尼校正值和错误发现率，我们发现rs4453709多态性（9型钠通道蛋白α亚基基因）的基因型与动机降低（AT携带者动机降低最为明显）和活动减少（AA携带者活动减少最少）有关。rs1801133（亚甲基四氢叶酸还原酶基因）或rs4597545（某基因）多态性的杂合基因型携带者，与不运动的同龄人相比，经常运动的人疲劳得分更低。rs7607967多态性纯合基因型（AA/GG基因型；某基因）的久坐不动者，与久坐行为较少的人相比，活动减少（疲劳的一个维度）更为明显。总体而言，本研究结果表明，遗传学和基因与体力活动的相互作用对纤维肌痛患者疲劳的影响较小。
