Department of General Pathomorphology, Medical University of Białystok, Kilińskiego 1, 15-089 Białystok, Poland.
Department of Clinical Laboratory Diagnostics, Medical University of Białystok, Kilińskiego 1, 15-089 Białystok, Poland.
Biomolecules. 2021 Apr 26;11(5):640. doi: 10.3390/biom11050640.
Tensins belong to the group of adhesion proteins that are involved in cell adhesion and migration, actin cytoskeleton maintenance and intercellular communication. TNS1, TNS2 and TNS3 proteins expression was evaluated in 90 patients with gastric cancer by immunohistochemistry method. TNS1 was more frequently present in non-differentiated tumors compared to poorly and moderately differentiated tumors ( = 0.016). TNS1 was also more often observed in metastatic tumors compared to those without distant metastases ( = 0.001). TNS2 was more common in moderately differentiated tumors than in poorly or non-differentiated ones ( = 0.041). TNS2 expression was also more frequently present in tumors with peritumoral inflammation ( = 0.041) and with concomitant infection ( = 0.023). In contrast, TNS3 protein was more prevalent in moderately than in poorly and non-differentiated tumors ( = 0.023). No significant relationship was found between tensins' expression and the overall survival rate of patients. TNS1 protein expression is associated with a poor-prognosis type of GC. Higher expression of TNS2 is accompanied by peritumoral inflammation and infection, which favor the development of GC of a better prognosis, similarly to higher TNS3 protein expression.
腱蛋白属于黏附蛋白家族，参与细胞黏附和迁移、肌动蛋白细胞骨架的维持和细胞间通讯。采用免疫组织化学方法检测 90 例胃癌患者中 TNS1、TNS2 和 TNS3 蛋白的表达。与低分化和中分化肿瘤相比，TNS1 在未分化肿瘤中更为常见（=0.016）。与无远处转移的肿瘤相比，TNS1 也更常出现在转移性肿瘤中（=0.001）。与低分化或未分化肿瘤相比，TNS2 更常见于中分化肿瘤（=0.041）。TNS2 的表达也更常出现在肿瘤周围炎症（=0.041）和合并感染的肿瘤中（=0.023）。相反，TNS3 蛋白在中分化肿瘤中的表达高于低分化和未分化肿瘤（=0.023）。腱蛋白的表达与患者的总生存率之间没有显著的相关性。TNS1 蛋白的表达与 GC 的预后不良类型相关。TNS2 表达水平较高与肿瘤周围炎症和感染有关，有利于预后较好的 GC 的发展，与 TNS3 蛋白表达较高的情况类似。
Zotero 插件
