School of Medicine, University of Liverpool, Liverpool, UK.
Department of Molecular and Clinical Cancer Medicine, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
J Cell Mol Med. 2023 Jul;27(13):1763-1774. doi: 10.1111/jcmm.17714. Epub 2023 Jun 9.
Tensin 1 was originally described as a focal adhesion adaptor protein, playing a role in extracellular matrix and cytoskeletal interactions. Three other Tensin proteins were subsequently discovered, and the family was grouped as Tensin. It is now recognized that these proteins interact with multiple cell signalling cascades that are implicated in tumorigenesis. To understand the role of Tensin 1-3 in neoplasia, current molecular evidence is categorized by the hallmarks of cancer model. Additionally, clinical data involving Tensin 1-3 are reviewed to investigate the correlation between cellular effects and clinical phenotype. Tensin proteins commonly interact with the tumour suppressor, DLC1. The ability of Tensin to promote tumour progression is directly correlated with DLC1 expression. Members of the Tensin family appear to have tumour subtype-dependent effects on oncogenesis; despite numerous data evidencing a tumour suppressor role for Tensin 2, association of Tensins 1-3 with an oncogenic role notably in colorectal carcinoma and pancreatic ductal adenocarcinoma is of potential clinical relevance. The complex interplay between these focal adhesion adaptor proteins and signalling pathways are discussed to provide an up to date review of their role in cancer biology.
腱蛋白 1 最初被描述为一种黏着斑衔接蛋白，在细胞外基质和细胞骨架相互作用中发挥作用。随后又发现了另外三种腱蛋白，该家族被归为腱蛋白。现在人们认识到，这些蛋白与多种细胞信号级联反应相互作用，这些信号级联反应与肿瘤发生有关。为了了解腱蛋白 1-3 在肿瘤发生中的作用，目前的分子证据是根据癌症模型的标志性特征进行分类的。此外，还回顾了涉及腱蛋白 1-3 的临床数据，以研究细胞效应与临床表型之间的相关性。腱蛋白通常与肿瘤抑制因子 DLC1 相互作用。腱蛋白促进肿瘤进展的能力与 DLC1 表达直接相关。腱蛋白家族的成员似乎对肿瘤发生具有肿瘤亚型依赖性的影响；尽管有大量数据表明腱蛋白 2 具有肿瘤抑制作用，但腱蛋白 1-3 与结直肠癌和胰腺导管腺癌中的致癌作用相关，这具有潜在的临床相关性。讨论了这些黏着斑衔接蛋白和信号通路之间的复杂相互作用，以提供其在癌症生物学中作用的最新综述。
