Sagan Karol Piotr, Andrysiak-Mamos Elżbieta, Tyburski Ernest, Sagan Leszek Michał, Syrenicz Anhelli
Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, 70-204 Szczecin, Poland.
Institute of Psychology, SWPS University of Social Sciences and Humanities, 03-815 Poznan, Poland.
J Clin Med. 2021 Apr 26;10(9):1879. doi: 10.3390/jcm10091879.
To determine the effect of transsphenoidal surgery on quality of life and sleep in patients with pituitary adenomas depending on tumor type and compression of the optic chiasm.
In this prospective study, patients with pituitary adenomas who were scheduled for transsphenoidal surgery completed the Short Form 36 Questionnaire, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale preoperatively and 7.5 (±1.5) months after surgery. Patients were analyzed based on tumor type and compression of the optic chiasm.
Significant improvements with large effect sizes were seen for patients with Cushing's disease in general health (Z = -2.37; = 0.018), vitality (Z = -2.05; = 0.041), and mental health (Z = -2.06; = 0.040). A significant deterioration with large effect size occurred in physical functioning (Z = -2.02; = 0.043) in patients with acromegaly. A significant improvement with medium effect size was seen in subjective sleep quality, (Z = -2.24; = 0.025), sleep duration (Z = -2.11; = 0.035), and habitual sleep efficiency (Z = -2.26; = 0.024) after decompression of the optic chiasm. Multiple significant correlations were observed between sleep parameters and Short Form 36 subscales before and after treatment.
Changes in quality of life during the follow-up period depend on tumor type. Circadian rhythm disturbances may resolve promptly after decompression of the optic chiasm. Quality of life in pituitary adenoma patients is associated with quality of sleep in many dimensions, thus implying that developing strategies to improve sleep quality could increase overall well-being and everyday functioning in pituitary adenoma patients.
根据肿瘤类型和视交叉受压情况，确定经蝶窦手术对垂体腺瘤患者生活质量和睡眠的影响。
在这项前瞻性研究中，计划接受经蝶窦手术的垂体腺瘤患者在术前以及术后7.5（±1.5）个月完成了36项简明健康状况调查问卷、匹兹堡睡眠质量指数和爱泼华嗜睡量表。根据肿瘤类型和视交叉受压情况对患者进行分析。
库欣病患者在总体健康（Z = -2.37；P = 0.018）、活力（Z = -2.05；P = 0.041）和心理健康（Z = -2.06；P = 0.040）方面有显著改善，效应量较大。肢端肥大症患者的身体功能出现显著恶化，效应量较大（Z = -2.02；P = 0.043）。视交叉减压术后，主观睡眠质量（Z = -2.24；P = 0.025）、睡眠时间（Z = -2.11；P = 0.035）和习惯性睡眠效率（Z = -2.26；P = 0.024）有显著改善，效应量中等。治疗前后睡眠参数与36项简明健康状况调查问卷各分量表之间存在多个显著相关性。
随访期间生活质量的变化取决于肿瘤类型。视交叉减压后昼夜节律紊乱可能迅速得到缓解。垂体腺瘤患者的生活质量在许多方面与睡眠质量相关，这意味着制定改善睡眠质量的策略可能会提高垂体腺瘤患者的整体幸福感和日常功能。
