Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Department of Endocrinology and Neuroendocrine Tumors, Medical University of Silesia, Katowice, Poland.
Endokrynol Pol. 2019;70(3):241-247. doi: 10.5603/EP.a2019.0003. Epub 2019 Jan 30.
The aim of the study was to determine which microperimetry and contrast sensitivity test parameters would prove the most valuable during diagnosing optic chiasm compression due to pituitary adenomas.
A control group comprised healthy individuals (Group 1). Patients with pituitary macroadenoma were divided into two groups: Group 2 - absent optic chiasm compression; and Group 3 - present optic chiasm compression detected on contrastenhanced magnetic resonance imaging (MRI). Each group comprised 20 patients (40 eyes), i.e. a total of 60 patients (120 eyes) were examined. A complete ocular examination, intraocular pressure, microperimetry, contrast sensitivity test, kinetic Goldmann visual field, and static Octopus visual field test were performed.
Group 1 and 2 variables showed no statistically significant differences with respect to the mean sensitivity (MS) and mean defect (MD) in microperimetry. After dividing the microperimetry area into quadrants, a difference was shown in the mean sensitivity of the lower-nasal quadrant (MS LN) and mean defect of the lower-nasal quadrant (MD LN) between those groups. Receiver operating characteristic (ROC) curves analysis revealed that the microperimetry parameter - MS LN as well as row D and E contrast sensitivity test could be highly specific in the assessment of early damage of the optic nerve in patients suffering from pituitary adenoma.
Microperimetry and contrast sensitivity test are non-invasive diagnostic investigations adjunctive to MRI, which facilitate detection of early chiasmal compression caused by pituitary adenomas.
本研究旨在确定哪些微视野和对比敏感度测试参数在诊断因垂体腺瘤引起的视交叉受压时最有价值。
一个对照组由健康个体组成（第 1 组）。患有垂体大腺瘤的患者被分为两组：第 2 组 - 视交叉无受压；第 3 组 - 经对比增强磁共振成像（MRI）检测到视交叉受压。每组包括 20 名患者（40 只眼），即共检查了 60 名患者（120 只眼）。进行了全面的眼部检查、眼压、微视野检查、对比敏感度测试、动态 Goldmann 视野和静态 Octopus 视野测试。
第 1 组和第 2 组变量在微视野中的平均敏感度（MS）和平均缺损（MD）方面没有统计学上的显著差异。将微视野区域分为四个象限后，显示出象限下-鼻侧（MS LN）的平均敏感度和象限下-鼻侧（MD LN）的平均缺损在两组之间存在差异。接收者操作特性（ROC）曲线分析显示，微视野参数 - MS LN 以及行 D 和 E 对比敏感度测试在评估垂体腺瘤患者视神经早期损伤方面具有高度特异性。
微视野和对比敏感度测试是 MRI 的辅助非侵入性诊断研究，有助于检测由垂体腺瘤引起的早期视交叉受压。
