Department of Cellular and Integrative Physiology.
Department of Anesthesiology.
Exerc Sport Sci Rev. 2021 Jul 1;49(3):213-222. doi: 10.1249/JES.0000000000000257.
This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins are secreted into the circulation within extracellular vesicles and taken up by remote cells, thus providing remote organs with cytoprotection against subsequent oxidative stress.
这篇综述探讨了一个假说,即慢性运动过程中反复的收缩-松弛会激活骨骼肌肌细胞中的核因子红细胞衍生 2 样 2(Nrf2),从而上调抗氧化酶。这些蛋白质通过细胞外囊泡分泌到循环中,并被远程细胞摄取,从而为远程器官提供针对随后氧化应激的细胞保护。