Fragliasso Valentina, Tameni Annalisa, Inghirami Giorgio, Mularoni Valentina, Ciarrocchi Alessia
Laboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
Front Oncol. 2021 Apr 13;11:643620. doi: 10.3389/fonc.2021.643620. eCollection 2021.
Defects in cytoskeleton functions support tumorigenesis fostering an aberrant proliferation and promoting inappropriate migratory and invasive features. The link between cytoskeleton and tumor features has been extensively investigated in solid tumors. However, the emerging genetic and molecular landscape of peripheral T cell lymphomas (PTCL) has unveiled several alterations targeting structure and function of the cytoskeleton, highlighting its role in cell shape changes and the aberrant cell division of malignant T cells. In this review, we summarize the most recent evidence about the role of cytoskeleton in PTCLs development and progression. We also discuss how aberrant signaling pathways, like JAK/STAT3, NPM-ALK, RhoGTPase, and Aurora Kinase, can contribute to lymphomagenesis by modifying the structure and the signaling properties of cytoskeleton.
细胞骨架功能缺陷支持肿瘤发生，促进异常增殖，并促进不适当的迁移和侵袭特性。细胞骨架与肿瘤特征之间的联系已在实体瘤中得到广泛研究。然而，外周T细胞淋巴瘤（PTCL）新出现的遗传和分子格局揭示了针对细胞骨架结构和功能的几种改变，突出了其在恶性T细胞的细胞形状变化和异常细胞分裂中的作用。在本综述中，我们总结了关于细胞骨架在PTCL发生和进展中作用的最新证据。我们还讨论了异常信号通路，如JAK/STAT3、NPM-ALK、RhoGTPase和极光激酶，如何通过改变细胞骨架的结构和信号特性促进淋巴瘤发生。
