前列腺素内二硫醚诱导的人血小板聚集。
Human platelet aggregation induced by prostaglandin endodisulfide.
作者信息
Okuma M, Yoshimoto T, Yamamoto S
出版信息
Prostaglandins. 1977 Nov;14(5):891-6. doi: 10.1016/0090-6980(77)90305-7.
The effect on human platelet functions of 9,11-dithio analogues of prostaglandin endoperoxide was investigated. Methyl (5Z, 9alpha, 11alpha, 13E, 15S)-9,11-epidithio-15-hydroxyprosta-5,13-dienoate induced platelet aggregation, while the 9beta,11beta-epimer was inactive. The platelet aggregation caused by the 9alpha,11alpha-dithio analogue was associated with serotonin release from platelets, and was inhibited by methyl ester of prostaglandin I2 (prostacyclin) but not by indomethacin.
研究了前列腺素内过氧化物的9,11 - 二硫代类似物对人血小板功能的影响。甲基(5Z, 9α, 11α, 13E, 15S)-9,11 - 环二硫代-15 - 羟基前列腺-5,13 - 二烯酸酯可诱导血小板聚集，而9β,11β - 差向异构体则无活性。由9α,11α - 二硫代类似物引起的血小板聚集与血小板中5 - 羟色胺的释放有关，并且被前列腺素I2（前列环素）甲酯抑制，但不被吲哚美辛抑制。
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