González-Gancedo J, Morales-Cané I, Rodríguez-Muñoz P M, Hidalgo-Lopezosa P, Del Rocío Valverde-León M, Fernández-Martínez M E, Fabbian F, Rodríguez-Borrego M A, López-Soto P J
Department of Nursing, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.
Eur Rev Med Pharmacol Sci. 2021 Apr;25(8):3377-3385. doi: 10.26355/eurrev_202104_25750.
The aim of the study was to find factors associated with the mortality of admission to the intensive care unit (ICU) in patients with COVID-19.
Retrospective observational study with a database of 1987 patients with COVID-19 who had attended the emergency department of a private hospital network between February 2020 and April 2020 were analyzed. Clinical variables and some laboratory parameters were studied. The Charlson and Elixhauser comorbidity indices were calculated. The dependent variables were mortality and admission to the ICU. A descriptive and correlational analysis was performed. Logistic regression models and Kaplan-Meier survival curves were established.
Positive correlations were observed between age, creatinine, and D-dimer levels, as well as with the scores obtained with the Charlson and Elixhauser indices. Differences in the levels of these parameters were also observed when analyzing variables such as mortality, sex or admission to the ICU. Mortality was associated with high creatinine and D-dimer levels and advanced age. Survival curves indicated longer survival in patients not admitted to the ICU, admitted to the hospital during the week, and in those with lower creatinine and D-dimer levels.
Mortality in Spanish patients with COVID-19 admitted to private hospitals was associated with high creatinine and D-dimer levels and advanced age. Longer survival was obtained on weekdays. This study provides valuable information on the management and nursing care of these patients in order to optimize resources in pandemic situations.
本研究旨在找出与新型冠状病毒肺炎（COVID-19）患者入住重症监护病房（ICU）死亡率相关的因素。
进行回顾性观察研究，分析了2020年2月至2020年4月期间在一家私立医院网络急诊科就诊的1987例COVID-19患者的数据库。研究了临床变量和一些实验室参数。计算了查尔森和埃利克斯豪泽合并症指数。因变量为死亡率和入住ICU情况。进行了描述性和相关性分析。建立了逻辑回归模型和 Kaplan-Meier 生存曲线。
观察到年龄、肌酐和 D-二聚体水平之间以及与查尔森和埃利克斯豪泽指数获得的分数之间呈正相关。在分析死亡率、性别或入住ICU等变量时，也观察到这些参数水平的差异。死亡率与高肌酐和 D-二聚体水平以及高龄相关。生存曲线表明，未入住ICU、在一周内入院且肌酐和 D-二聚体水平较低的患者生存时间更长。
入住私立医院的西班牙COVID-19患者的死亡率与高肌酐和 D-二聚体水平以及高龄相关。工作日的生存时间更长。本研究为这些患者的管理和护理提供了有价值的信息，以便在大流行情况下优化资源。
