Design, synthesis and antibacterial evaluation of ocotillol derivatives with polycyclic nitrogen-containing groups.

With the increasing abuse of antibacterial drugs, multidrug-resistant bacteria have become a burden on human health and the healthcare system. To find alternative compounds effective against hospital-acquired methicillin-resistant  (HA-MRSA), novel derivatives of ocotillol were synthesized. Ocotillol derivatives with polycyclic nitrogen-containing groups were synthesized and evaluated for antibacterial activity. Compounds exhibited potent antibacterial activity against HA-MRSA, with MIC = 8-64 μg/ml. Additionally, a combination of compound and the commercially available antibiotic kanamycin showed synergistic inhibitory effects, with a fractional inhibitory concentration index of ≤0.375. Compound has a strong inhibitory effect, and this derivative has potential for use as a pharmacological tool to explore antibacterial mechanisms.