草药、食物和膳食补充剂与癌症治疗之间潜在的细胞色素 P450 介导的药代动力学相互作用。
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments.
机构信息
Sorbonne Université, INSERM CIC Paris-Est, AP-HP, ICAN, Pitié-Salpêtrière Hospital, Department of Pharmacology, F-75013, Paris, France; CLIP² Galilée, Department of Medical Oncology Pitié-Salpêtrière Hospital, F-75013, Paris, France.
Sorbonne Université, INSERM CIC Paris-Est, AP-HP, ICAN, Pitié-Salpêtrière Hospital, Department of Pharmacology, F-75013, Paris, France.
出版信息
Crit Rev Oncol Hematol. 2021 Oct;166:103342. doi: 10.1016/j.critrevonc.2021.103342. Epub 2021 Apr 28.
Herbs, food and dietary supplements (HFDS), can interact significantly with anticancer drug treatments via cytochrome p450 isoforms (CYP) CYP3A4, CYP2D6, CYP1A2, and CYP2C8. The objective of this review was to assess the influence of HFDS compounds on these cytochromes. Interactions with CYP activities were searched for 189 herbs and food products, 72 dietary supplements in Web of Knowledge® databases. Analyses were made from 140 of 3125 clinical trials and 236 of 3374 in vitro, animal model studies or case reports. 18 trials were found to report direct interactions between 9 HFDS with 8 anticancer drugs. 21 HFDS were found to interact with CYP3A4, a major metabolic pathway for many anticancer drugs. All 261 HFDS were classified for their interaction with the main cytochromes P450 involved in the metabolism of anticancer drugs. We provided an easy-to-use colour-coded table to easily match potential interactions between 261 HFDS and 117 anticancer drugs.
草药、食品和膳食补充剂（HFDS）可通过细胞色素 P450 同工酶（CYP）CYP3A4、CYP2D6、CYP1A2 和 CYP2C8 与抗癌药物治疗产生显著相互作用。本综述的目的是评估 HFDS 化合物对这些细胞色素的影响。在 Web of Knowledge®数据库中搜索了 189 种草药和食品产品、72 种膳食补充剂与 CYP 活性的相互作用。从 3125 项临床试验中的 140 项和 3374 项体外、动物模型研究或病例报告中进行了分析。发现 18 项试验报告了 9 种 HFDS 与 8 种抗癌药物之间的直接相互作用。发现 21 种 HFDS 与 CYP3A4 相互作用，CYP3A4 是许多抗癌药物的主要代谢途径。将所有 261 种 HFDS 按照其与参与抗癌药物代谢的主要细胞色素 P450 的相互作用进行分类。我们提供了一个易于使用的彩色编码表格，可轻松匹配 261 种 HFDS 和 117 种抗癌药物之间的潜在相互作用。
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