National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
Ultrason Sonochem. 2021 Jun;74:105570. doi: 10.1016/j.ultsonch.2021.105570. Epub 2021 Apr 20.
Ultrasound-mediated method, which can effectively disperse agglomerates or even eliminate agglomeration, has received more and more attentions in industrial crystallization. However, the ultrasound-mediated de-agglomeration mechanism has not been well understood, and no general conclusions have been drawn. In this study, the crystallization and de-agglomeration process of ceftezole sodium agglomerates under ultrasound irradiation were systematically investigated. Kapur function was selected to investigate the de-agglomeration process under different ultrasonic powers. The results revealed that ultrasound could efficiently inhibit agglomeration. Besides, the de-agglomeration of large sized agglomerate particles was found to be easier to occur in comparison with small sized particles due to its higher specific breakage rate. Finally, the de-agglomeration mechanism under ultrasonic irradiation was proposed on the basis of the calculated cumulative breakage functions.
超声介导方法可以有效地分散团聚体甚至消除团聚体，在工业结晶中受到越来越多的关注。然而，超声介导的解团聚机制尚未得到很好的理解，也没有得出一般性的结论。在本研究中，系统地研究了头孢替唑钠团聚体在超声辐射下的结晶和解团聚过程。选择卡普尔函数研究不同超声功率下的解团聚过程。结果表明，超声能有效地抑制团聚。此外，由于大粒径团聚体的比破碎率较高，发现大粒径团聚体的解团聚比小粒径团聚体更容易发生。最后，根据计算的累积破碎函数提出了超声辐射下的解团聚机制。
