Okada K, Hoshino K, Hitomi S
Department of Anatomy, Kyoto University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1988 Mar;89(3):416-22.
The nuclear DNA content of normal thymuses and thymomas were measured by microphotometry. The DNA histograms were analyzed for 1) peak values, 2) cell with DNA contents of 4C or more (tetraploidy), and 3) average histograms. The DNA histograms of normal thymuses had peak values around 2C. However, the peak value on thymomal histograms moved to the 4C region (tetraploidy). Advances in stages were followed by an increase in the number of cells with high DNA contents. The number of cells with DNA contents of 8C or more (octaploidy) were significant only in stage III. Thymomal histograms were different from those of normal thymuses. The DNA histograms of thymomas changed with advances in stage, which may indicate that the epithelial cells of thymomas become neoplastic.
采用显微光度测定法测量正常胸腺和胸腺瘤的核DNA含量。对DNA直方图进行分析，观察：1）峰值；2）DNA含量为4C或更高的细胞（四倍体）；3）平均直方图。正常胸腺的DNA直方图峰值约为2C。然而，胸腺瘤直方图的峰值移至4C区域（四倍体）。随着分期进展，DNA含量高的细胞数量增加。DNA含量为8C或更高的细胞（八倍体）数量仅在III期显著。胸腺瘤的直方图与正常胸腺不同。胸腺瘤的DNA直方图随分期进展而变化，这可能表明胸腺瘤的上皮细胞发生了肿瘤性改变。
