Department of Psychology, Saint Mary's University, Halifax, NS, Canada.
Department of Biomedical Science, University of Ottawa, Ottawa, ON, Canada.
Psychopharmacology (Berl). 2022 May;239(5):1279-1288. doi: 10.1007/s00213-021-05843-6. Epub 2021 May 1.
Long-term cannabis use has been associated with the appearance of psychotic symptoms and schizophrenia-like cognitive impairments; however these studies may be confounded by concomitant use of tobacco by cannabis users. We aimed to determine if previously observed cannabis-associated deficits in sensory gating would be seen in cannabis users with no history of tobacco use, as evidenced by changes in the P50, N100, and P200 event-related potentials. A secondary objective of this study was to examine the effects of acute nicotine administration on cannabis users with no tobacco use history.
Three components (P50, N100, P200) of the mid-latency auditory-evoked response (MLAER) were elicited by a paired-stimulus paradigm in 43 healthy, non-tobacco smoking male volunteers between the ages of 18-30. Cannabis users (CU, n = 20) were administered nicotine (6 mg) and placebo gum within a randomized, double-blind design. Non-cannabis users (NU, n = 23) did not receive nicotine.
Between-group sensory gating effects were only observed for the N100, with CUs exhibiting a smaller N100 to S of the paired stimulus paradigm, in addition to reduced dN100 (indicating poorer gating). Results revealed no significant sensory gating differences with acute administration of nicotine compared to placebo cannabis conditions.
These findings suggest a relationship between gating impairment and cannabis use; however, acute nicotine administration nicotine does not appear to impact sensory gating function.
长期使用大麻与出现精神病症状和类似精神分裂症的认知障碍有关；然而，这些研究可能因大麻使用者同时使用烟草而受到混淆。我们旨在确定在没有吸烟史的大麻使用者中是否会出现先前观察到的与大麻相关的感觉门控缺陷，这可以通过 P50、N100 和 P200 事件相关电位的变化来证明。本研究的次要目的是研究急性尼古丁给药对无吸烟史的大麻使用者的影响。
在年龄在 18-30 岁之间的 43 名健康、不吸烟的男性志愿者中，通过双刺激范式引出中潜伏期听觉诱发电位（MLAER）的三个成分（P50、N100、P200）。大麻使用者（CU，n=20）在随机、双盲设计中接受尼古丁（6 毫克）和安慰剂口香糖。非大麻使用者（NU，n=23）未接受尼古丁。
仅在 N100 观察到组间感觉门控效应，CU 对双刺激范式的 S 表现出较小的 N100，此外 dN100 降低（表明门控较差）。与安慰剂大麻条件相比，急性尼古丁给药与尼古丁相比，结果未显示出明显的感觉门控差异。
这些发现表明门控障碍与大麻使用之间存在关系；然而，急性尼古丁给药似乎不会影响感觉门控功能。
