Department of Surgical Sciences and Integrated Diagnostics, Laser Therapy Centre, University of Genoa, Genoa, Italy; Department of Periodontology, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, Maharashtra, India.
Department of Surgical Sciences and Integrated Diagnostics, Laser Therapy Centre, University of Genoa, Genoa, Italy.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102314. doi: 10.1016/j.pdpdt.2021.102314. Epub 2021 Apr 29.
Limitations of scaling and root planing (SRP) have directed research to utilize additional therapies to enhance conventional techniques. The present systematic review was conducted to evaluate and present a comprehensive overview on effectiveness of antimicrobial photodynamic therapy (aPDT) in the management of aggressive periodontitis (AgP).
The PRISMA statement guidelines and Cochrane Collaboration recommendations were followed to conduct this systematic review. The review protocol is registered in PROSPERO (CRD 42019143316). A structured electronic and manual search strategy was implied to gather the relevant published data on in vivo human RCTs from their earliest records until 31st October 2019. Relevant data was extracted from the eligible studies, analysed and impartially appraised for its quality.
Eleven papers met the eligibility criteria and included in this review. The data on standardized study protocol, ideal photosensitizer (PS) dye-wavelength combination, optimal parameters was inconclusive and a high risk of bias in majority of the studies noted, which are fundamental in establishing a standardized and replicable protocol.
Ultimately researchers should conduct well-designed and robust RCTs performed by trained clinicians in order to determine the effectiveness of aPDT, if any, after acknowledging the drawbacks highlighted in this systematic review.
由于刮治和根面平整术（SRP）存在局限性，因此研究人员转而寻求其他治疗方法来增强传统技术。本系统评价旨在评估并全面概述光动力疗法（aPDT）在侵袭性牙周炎（AgP）治疗中的有效性。
本系统评价遵循 PRISMA 声明指南和 Cochrane 协作组的建议进行。综述方案已在 PROSPERO（CRD42019143316）中注册。采用结构化的电子和手动搜索策略，从最早的记录到 2019 年 10 月 31 日，收集有关体内人类 RCT 的相关已发表数据。从合格研究中提取相关数据，对其进行分析和客观评估。
符合纳入标准的 11 篇论文纳入本综述。关于标准化研究方案、理想的光敏剂（PS）染料波长组合、最佳参数的数据尚无定论，而且大多数研究存在高度偏倚风险，这些都是建立标准化和可复制方案的基础。
最终，研究人员应进行精心设计和稳健的 RCT，由经过培训的临床医生进行，以确定 aPDT 是否有效，如果有效的话，需要考虑到本系统评价中强调的缺点。
