Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, Metabolism (AGEM), Amsterdam, the Netherlands.
Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany.
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158960. doi: 10.1016/j.bbalip.2021.158960. Epub 2021 Apr 29.
Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes, mediates the uptake of conjugated bile acids. In conditions where bile flow is impaired (cholestasis), pharmacological inhibition of NTCP-mediated bile acid influx is suggested to reduce hepatocellular damage due to bile acid overload. Furthermore, NTCP has been shown to play an important role in hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infection by functioning as receptor for viral entry into hepatocytes. This review provides a summary of current molecular insight into the regulation of NTCP expression at the plasma membrane, hepatic bile acid transport, and NTCP-mediated viral infection.
肝细胞和肠细胞表达的转运蛋白在维持胆汁酸的肠肝循环中起着关键作用。牛磺胆酸钠共转运多肽（NTCP），仅在肝细胞的基底外侧表达，介导结合胆汁酸的摄取。在胆汁流动受损（胆汁淤积）的情况下，建议抑制 NTCP 介导的胆汁酸内流的药理学方法，以减少由于胆汁酸过载导致的肝细胞损伤。此外，NTCP 已被证明在乙型肝炎病毒（HBV）和丁型肝炎病毒（HDV）感染中发挥重要作用，作为病毒进入肝细胞的受体。本综述总结了目前对 NTCP 在质膜表达、肝内胆汁酸转运和 NTCP 介导的病毒感染中的调节的分子认识。
