有证据表明，大鼠海马组织中乙酰胆碱的自发释放是由载体介导的。
Evidence to suggest that the spontaneous release of acetylcholine from rat hippocampal tissue is carrier-mediated.
作者信息
Ivy M T, Carroll P T
机构信息
Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock 79430.
出版信息
Neurochem Res. 1988 Apr;13(4):325-8. doi: 10.1007/BF00972481.
The effect of L- and D-stereoisomers of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) on the spontaneous release of acetylcholine (ACh) from rat hippocampal tissue was studied. L-AH 5183 was approximately 100 times more potent than was D-AH 5183 in reducing spontaneous ACh release. Spontaneous ACh release was also temperature dependent. These results may suggest that the spontaneous release of ACh from brain tissue is carrier-mediated.
研究了2-(4-苯基哌啶基)环己醇（AH 5183）的L型和D型立体异构体对大鼠海马组织中乙酰胆碱（ACh）自发释放的影响。在减少ACh自发释放方面，L-AH 5183的效力比D-AH 5183强约100倍。ACh的自发释放也与温度有关。这些结果可能表明，脑组织中ACh的自发释放是由载体介导的。
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