• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

有证据表明，大鼠海马组织中乙酰胆碱的自发释放是由载体介导的。

Evidence to suggest that the spontaneous release of acetylcholine from rat hippocampal tissue is carrier-mediated.

作者信息

Ivy M T, Carroll P T

机构信息

Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock 79430.

出版信息

Neurochem Res. 1988 Apr;13(4):325-8. doi: 10.1007/BF00972481.

DOI:10.1007/BF00972481
PMID:3393262
Abstract

The effect of L- and D-stereoisomers of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) on the spontaneous release of acetylcholine (ACh) from rat hippocampal tissue was studied. L-AH 5183 was approximately 100 times more potent than was D-AH 5183 in reducing spontaneous ACh release. Spontaneous ACh release was also temperature dependent. These results may suggest that the spontaneous release of ACh from brain tissue is carrier-mediated.

摘要

研究了2-(4-苯基哌啶基)环己醇（AH 5183）的L型和D型立体异构体对大鼠海马组织中乙酰胆碱（ACh）自发释放的影响。在减少ACh自发释放方面，L-AH 5183的效力比D-AH 5183强约100倍。ACh的自发释放也与温度有关。这些结果可能表明，脑组织中ACh的自发释放是由载体介导的。

相似文献

1
Evidence to suggest that the spontaneous release of acetylcholine from rat hippocampal tissue is carrier-mediated.有证据表明，大鼠海马组织中乙酰胆碱的自发释放是由载体介导的。
Neurochem Res. 1988 Apr;13(4):325-8. doi: 10.1007/BF00972481.
2
The effect of 2-(4-phenylpiperidino)cyclohexanol (AH-5183), tityustoxin and ouabain on the release of acetylcholine and its mobilization from cytoplasmic and vesicular pools of rat brain cortical slices.2-(4-苯基哌啶基)环己醇（AH-5183）、毒蛛毒素和哇巴因对大鼠脑皮质切片中乙酰胆碱释放及其从细胞质和囊泡池动员的影响。
Neurosci Lett. 1990 Mar 26;111(1-2):195-200. doi: 10.1016/0304-3940(90)90367-i.
3
Effect of 2-(4-phenylpiperidino)cyclohexanol (AH 5183) on the veratridine-induced increase in acetylcholine synthesis by rat hippocampal tissue.2-(4-苯基哌啶基)环己醇（AH 5183）对藜芦碱诱导的大鼠海马组织乙酰胆碱合成增加的影响。
J Neurochem. 1988 Sep;51(3):808-19. doi: 10.1111/j.1471-4159.1988.tb01816.x.
4
In favour of the vesicular hypothesis: neurochemical evidence that vesamicol (AH5183) inhibits stimulation-evoked release of acetylcholine from neuromuscular junction.支持囊泡假说的证据：神经化学证据表明，vesamicol（AH5183）可抑制神经肌肉接头处由刺激诱发的乙酰胆碱释放。
Br J Pharmacol. 1989 Nov;98(3):898-902. doi: 10.1111/j.1476-5381.1989.tb14619.x.
5
Quinacrine and 2-(4-phenylpiperidino)cyclohexanol (AH5183) inhibit acetylcholine release and synthesis in rat brain slices.喹吖因和2-(4-苯基哌啶基)环己醇(AH5183)抑制大鼠脑片乙酰胆碱的释放和合成。
Mol Pharmacol. 1986 Jan;29(1):45-51.
6
Effect of 2-(4-phenylpiperidino)cyclohexanol on acetylcholine release and subcellular distribution in rat striatal slices.2-(4-苯基哌啶基)环己醇对大鼠纹状体切片中乙酰胆碱释放及亚细胞分布的影响
J Neurochem. 1986 Nov;47(5):1627-33. doi: 10.1111/j.1471-4159.1986.tb00805.x.
7
Acetylcholine synthesis is modulated by acetylcholine content of cytosolic fraction but not by that of releasable fraction.乙酰胆碱的合成受胞质部分乙酰胆碱含量的调节，而不受可释放部分乙酰胆碱含量的调节。
Neurosci Lett. 1992 Sep 14;144(1-2):127-9. doi: 10.1016/0304-3940(92)90732-m.
8
Reduction of quantal size by vesamicol (AH5183), an inhibitor of vesicular acetylcholine storage.囊泡乙酰胆碱储存抑制剂维塞克醇（AH5183）对量子大小的降低作用。
Brain Res. 1986 Oct 15;385(1):189-92. doi: 10.1016/0006-8993(86)91565-9.
9
Acetylcholine mobilization in a sympathetic ganglion in the presence and absence of 2-(4-phenylpiperidino)cyclohexanol (AH5183).在存在和不存在2-(4-苯基哌啶基)环己醇（AH5183）的情况下，交感神经节中乙酰胆碱的动员情况。
J Neurochem. 1988 Jan;50(1):112-21. doi: 10.1111/j.1471-4159.1988.tb13237.x.
10
The nature and origin of calcium-insensitive miniature end-plate potentials at rodent neuromuscular junctions.啮齿动物神经肌肉接头处钙不敏感型微小终板电位的性质与起源
J Physiol. 1986 Dec;381:607-18. doi: 10.1113/jphysiol.1986.sp016346.

本文引用的文献

1
Subcellular origin of cholinergic transmitter release from mouse brain.小鼠脑内胆碱能递质释放的亚细胞起源
Science. 1980 Nov 7;210(4470):641-2. doi: 10.1126/science.7433989.
2
Aging decreases oxidative metabolism and the release and synthesis of acetylcholine.衰老会降低氧化代谢以及乙酰胆碱的释放和合成。
J Neurochem. 1981 Oct;37(4):978-84. doi: 10.1111/j.1471-4159.1981.tb04484.x.
3
Evidence for the role of non-quantal acetylcholine in the maintenance of the membrane potential of rat skeletal muscle.非量子化乙酰胆碱在维持大鼠骨骼肌膜电位中的作用的证据。
J Physiol. 1982 May;326:285-96. doi: 10.1113/jphysiol.1982.sp014192.
4
Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles.纯化的电鳐电器官突触小泡中乙酰胆碱转运系统的药理学特性
Mol Pharmacol. 1983 Jul;24(1):48-54.
5
Depolarization of mouse forebrain minces with veratridine and high K+: failure to stimulate the Ca2+ independent, spontaneous release of acetylcholine from the cytoplasm due to hydrolysis of the acetylcholine stored there.用藜芦碱和高钾使小鼠前脑切碎组织去极化：由于储存于其中的乙酰胆碱水解，未能刺激细胞质中与钙无关的乙酰胆碱自发释放。
Brain Res. 1984 Jan 23;291(2):261-72. doi: 10.1016/0006-8993(84)91258-7.
6
Uptake, metabolism, and releasability of ethyl analogues of homocholine by rat brain.大鼠脑对高胆碱乙酯类似物的摄取、代谢及释放能力
J Neurochem. 1984 Oct;43(4):1143-51. doi: 10.1111/j.1471-4159.1984.tb12855.x.
7
Veratridine-induced release of acetylcholine from mouse forebrain minces: dependence on the hydrolysis of cytoplasmic acetylcholine for a source of choline.藜芦碱诱导小鼠前脑切碎组织释放乙酰胆碱：胆碱来源依赖于细胞质乙酰胆碱的水解。
Brain Res. 1984 Oct 29;321(1):55-62. doi: 10.1016/0006-8993(84)90680-2.
8
Neurotrophic regulation of two properties of skeletal muscle by impulse-dependent and spontaneous acetylcholine transmission.通过冲动依赖性和自发性乙酰胆碱传递对骨骼肌两种特性进行神经营养调节。
J Neurosci. 1982 Feb;2(2):232-43. doi: 10.1523/JNEUROSCI.02-02-00232.1982.
9
Spontaneous and potassium-induced release of acetylcholine from mouse forebrain minces.乙酰胆碱从小鼠前脑切碎组织中的自发释放及钾离子诱导释放
Neuroscience. 1981;6(12):2555-9. doi: 10.1016/0306-4522(81)90101-9.
10
Correlations between Na+-K+ ATPase activity and acetylcholine release in rat cortical synaptosomes.大鼠皮层突触体中钠钾ATP酶活性与乙酰胆碱释放之间的相关性。
J Neurochem. 1981 Feb;36(2):467-75. doi: 10.1111/j.1471-4159.1981.tb01616.x.