乙醇会增加突触体游离钙浓度。
Ethanol increases synaptosomal free calcium concentration.
作者信息
Davidson M, Wilce P, Shanley B
机构信息
Department of Biochemistry, University of Queensland, St. Lucia, Australia.
出版信息
Neurosci Lett. 1988 Jun 29;89(2):165-9. doi: 10.1016/0304-3940(88)90375-8.
The effect of ethanol on synaptosomal free calcium concentration [( Ca2+]i) and 45Ca2+ uptake was studied in vitro. Synaptosomes were prepared from forebrains of adult rats and incubated in the presence of ethanol 50-500 mM. [Ca2+]i determined by means of the Ca2+-sensitive dye, fura-2, was increased by ethanol in polarized and depolarized synaptosomes, whereas 45Ca2+ uptake was decreased. The results suggest that ethanol may influence neuronal calcium homeostasis by increasing rather than decreasing [Ca2+]i.
在体外研究了乙醇对突触体游离钙浓度[Ca2+]i和45Ca2+摄取的影响。从成年大鼠的前脑制备突触体，并在50 - 500 mM乙醇存在下孵育。通过钙敏感染料fura - 2测定的[Ca2+]i在极化和去极化的突触体中均被乙醇升高，而45Ca2+摄取则降低。结果表明，乙醇可能通过升高而非降低[Ca2+]i来影响神经元钙稳态。
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