Rice D C
Toxicology Research Division, Health and Welfare Canada, Ottawa, Ontario.
Neurotoxicology. 1988 Spring;9(1):105-7.
Simple visual reaction time was measured in a group of adult monkeys (Macaca fascicularis) dosed continuously with lead from birth onward, and in matched controls. Blood lead concentrations had been stable for 6 years at 33 micrograms/dl at the time of testing. The monkey was required to make contact with a stainless steel bar to initiate a trial, and release it at the onset of a visual cue. Delays between one and 13 sec were interposed between the initiation of the trial and the onset of the cue light in a semi-random manner over the course of each session. Reaction times did not differ between groups. Reinforcement was then made contingent upon progressively shorter reaction times until performance deteriorated to a specified level. Treated monkeys were able to respond as rapidly as controls. Simple reaction time proved insensitive to impairment by lead exposure, in contrast to other measures of performance tested in this group of monkeys.
对一组从出生起就持续摄入铅的成年猕猴（食蟹猴）以及匹配的对照组测量了简单视觉反应时间。在测试时，血铅浓度在33微克/分升的水平稳定了6年。要求猕猴接触一根不锈钢棒以开始一次试验，并在视觉提示出现时松开它。在每个试验过程中，以半随机的方式在试验开始和提示光出现之间插入1到13秒的延迟。两组之间的反应时间没有差异。然后根据逐渐缩短的反应时间给予强化，直到表现下降到指定水平。接受治疗的猕猴能够和对照组一样快速做出反应。与在这组猕猴中测试的其他性能指标相比，简单反应时间被证明对铅暴露造成的损害不敏感。
