Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, GA, USA.
Laboratory for Toxicology, Ref4U, Ghent University, Ghent, Belgium.
Clin Chim Acta. 2021 Aug;519:183-186. doi: 10.1016/j.cca.2021.04.019. Epub 2021 Apr 30.
Measurements of thyroid stimulating hormone (TSH) and free thyroxine (fT4) are critical for the early detection of thyroid diseases and for monitoring treatment. The IFCC Committee for Standardization of Thyroid Function Tests (C-STFT) established reference systems for TSH harmonization and FT4 standardization, and is now working national partners on implementing these reference systems. These implementation activities include the maintenance of the reference systems, their use to standardize and harmonize assays, and educational activities to inform stakeholders about anticipated changes in measurement values as a result of standardization and harmonization. The IFCC C-STFT formed a network of reference laboratories for FT4 and is creating a new harmonization panel for TSH. The U.S. Centers for Disease Control and Prevention is a member of the reference laboratory network and is launching a formal standardization program for FT4. In Japan, national organizations successfully implemented TSH harmonization and established harmonized reference intervals for TSH. The C-STFT made available on its website research findings about potential concerns, communication needs and benefits of FT4 standardization and is assisting local organizations with communicating changes related to these standardization and harmonization efforts. Implementation of fT4 standardization and TSH harmonization is a complex, continuous task that requires collaboration with IVD manufacturers, laboratories, physicians and health care providers. C-STFT is working successfully with national organizations and local groups on improving FT4 and TSH measurements.
测量促甲状腺激素（TSH）和游离甲状腺素（fT4）对于甲状腺疾病的早期检测和治疗监测至关重要。国际临床化学联合会甲状腺功能标准化委员会（C-STFT）为 TSH 协调和 FT4 标准化建立了参考系统，并正在与各国合作伙伴合作实施这些参考系统。这些实施活动包括维护参考系统、使用参考系统对检测进行标准化和协调，以及开展教育活动，使利益攸关方了解标准化和协调对测量值的预期影响。IFCC C-STFT 为 FT4 建立了参考实验室网络，并正在为 TSH 创建一个新的协调小组。美国疾病控制与预防中心是参考实验室网络的成员，正在启动 FT4 的正式标准化计划。在日本，国家组织成功地实施了 TSH 协调，并为 TSH 建立了协调的参考区间。C-STFT 在其网站上公布了关于 FT4 标准化的潜在问题、沟通需求和收益的研究结果，并协助当地组织就这些标准化和协调工作进行沟通。FT4 标准化和 TSH 协调的实施是一项复杂的、持续的任务，需要与体外诊断制造商、实验室、医生和医疗保健提供者合作。C-STFT 正在与各国组织和地方团体合作，成功地改进 FT4 和 TSH 的测量。
