Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mol Cell Endocrinol. 2021 Jul 1;531:111301. doi: 10.1016/j.mce.2021.111301. Epub 2021 Apr 29.
Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men. BPH patients exhibit an increased risk of vertebral and hip fractures, which are most attributable to pre-existing osteoporosis. However, the relationship between BPH and osteoporosis is still unknown. Here we found that osteocytes, the most abundant bone cells, promoted BPH development by secreting exosomes. In vitro, osteocyte exosomes (OCY-Exo) directly promoted cell proliferation of a prostate epithelial cell line BPH-1 and a macrophage cell line RAW264.7, OCY-Exo also stimulated macrophage-induced proliferation of BPH-1 cells. In vivo, intramedullary injection of OCY-Exo accumulated in prostate. Intravenous administration of OCY-Exo exacerbated testosterone-induced BPH in C57BL/6J mice. Our study uncovers the role of OCY-Exo as a stimulator of BPH, suggesting a novel mechanism in bone-prostate communication.
良性前列腺增生（BPH）是老年男性最常见的疾病之一。BPH 患者发生椎体和髋部骨折的风险增加，这主要归因于先前存在的骨质疏松症。然而，BPH 和骨质疏松症之间的关系尚不清楚。在这里，我们发现骨细胞，即最丰富的骨细胞，通过分泌外泌体促进 BPH 的发展。在体外，骨细胞外泌体（OCY-Exo）直接促进前列腺上皮细胞系 BPH-1 和巨噬细胞系 RAW264.7 的细胞增殖，OCY-Exo 还刺激巨噬细胞诱导的 BPH-1 细胞增殖。在体内，OCY-Exo 蓄积在骨髓内注射部位。静脉给予 OCY-Exo 加剧了 C57BL/6J 小鼠睾丸酮诱导的 BPH。我们的研究揭示了 OCY-Exo 作为 BPH 刺激物的作用，提示了骨-前列腺通讯中的一种新机制。
