Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
Medical Statistics, Epirus Science and Technology Park Campus of the University of Ioannina, Ioannina, Greece.
J Steroid Biochem Mol Biol. 2021 Jul;211:105903. doi: 10.1016/j.jsbmb.2021.105903. Epub 2021 Apr 30.
We aimed to evaluate sex differences in changes of lipid profiles in a cohort of metabolically healthy adults following Orthodox fasting (OF), as well as to assess a potential role of vitamin D status in mediating these variations. 45 individuals (24 premenopausal females, 53.3 %) with mean age 48.3 ± 9.1 years and mean Body Mass Index 28.7 ± 5.8 kg/m were prospectively followed for 12 weeks. Anthropometry, dietary and biochemical data regarding serum lipids, and vitamin D status were collected at baseline, 7 weeks after the implementation of OF, and 5 weeks after fasters returned to their standard dietary habits (12 weeks from baseline). According to 25-hydroxy-vitamin D [25(OH)D] measurements, participants were divided into two groups: those with concentrations above and below the median of values. Females with 25(OH)D concentrations below the median manifested a non-significant reduction by approximately 15 % in total and low-density lipoprotein cholesterol during the fasting period, followed by a significant increase 5 weeks after OF cessation (170.7 vs. 197.5 and 99.6 vs. 121.0 mg/dl respectively, p < 0.001). In contrast, males with 25(OH)D levels below the median demonstrated an inverse, non-significant trend of increase in lipid concentrations during the whole study period. Our findings suggest strikingly different inter-gender lipid responses to a dietary model of low-fat, mediated by vitamin D status. Further studies are necessary to reveal the underlying mechanisms and assess the importance of these differences with respect to cardiovascular health and the benefit of vitamin D supplementation strategies.
我们旨在评估在遵循东正教斋戒（OF）的代谢健康成年人队列中，血脂谱变化的性别差异，以及评估维生素 D 状态在介导这些变化中的潜在作用。45 名个体（24 名绝经前女性，53.3%），平均年龄 48.3±9.1 岁，平均体重指数 28.7±5.8kg/m，前瞻性随访 12 周。在基线、实施 OF 后 7 周以及禁食者恢复标准饮食习惯后 5 周（从基线开始 12 周）收集了人体测量学、饮食和血清脂质及维生素 D 状态的生化数据。根据 25-羟维生素 D [25(OH)D] 测量结果，将参与者分为两组：维生素 D 浓度高于和低于中位数的组。25(OH)D 浓度低于中位数的女性在禁食期间总胆固醇和低密度脂蛋白胆固醇大约降低了 15%，之后在 OF 停止后 5 周显著升高（分别为 170.7 对 197.5 和 99.6 对 121.0mg/dl，p<0.001）。相比之下，25(OH)D 水平低于中位数的男性在整个研究期间血脂浓度呈相反的、非显著升高趋势。我们的研究结果表明，维生素 D 状态介导的低脂饮食模式下，性别间的脂质反应存在明显差异。需要进一步的研究来揭示潜在的机制，并评估这些差异对心血管健康和维生素 D 补充策略的重要性。
