Reznikov A G, Korpacheva T I
Probl Endokrinol (Mosk). 1988 Mar-Apr;34(2):64-7.
The effect of prolonged administration of antiandrogen flutamide (FT) on testosterone (T) metabolism in the prostate (P) of intact and castrated rats and animals receiving androgens with substitution purpose was studied. In intact animals the production of dehydrotestosterone from labeled T in vitro was decreased in 30 days by 50%. The influence of FT on 5 alpha-reductase was shown to be determined by the blockade of androgenic effects. Proceeding from the results of experiments with FT and its hydroxylated metabolite added to incubated homogenates of the prostate of intact animals it was assumed that FT hydroxylated metabolite mediated FT influence on T metabolism.
研究了长期给予抗雄激素氟他胺（FT）对完整大鼠、去势大鼠以及接受雄激素替代治疗的动物前列腺（P）中睾酮（T）代谢的影响。在完整动物中，体外由标记T生成脱氢睾酮的量在30天内降低了50%。FT对5α-还原酶的影响表明是由雄激素效应的阻断所决定的。根据将FT及其羟基化代谢产物添加到完整动物前列腺孵育匀浆中的实验结果推测，FT的羟基化代谢产物介导了FT对T代谢的影响。
