Selalmaz Melek, Uysal Gulzade, Zubarioglu Umut, Bulbul Ali
Department of Pediatrics, Division of Neonatology, University of Health Sciences Turkey, Sisli Hamidiye Etfal Teaching and Research Hospital, Istanbul, Turkey.
Department of Nursing, Okan University, Institute of Health Sciences, Istanbul, Turkey.
Sisli Etfal Hastan Tıp Bul. 2021 Mar 17;55(1):115-121. doi: 10.14744/SEMB.2020.31549. eCollection 2021.
The aim of this study was to determine the effect of intermittent bolus feeding and continuous feeding models on early growth and discharge time in very low birth weight infants.
The study was designed as a prospective, randomized, and controlled study. Infants born in our hospital with birth weight below 1500 g within a 1 year period were included in the study. The number of samples was determined by power analysis. Babies were randomized according to birth weight and fed with intermittent bolus feeding and continuous feeding models. Demographic characteristics, clinical findings, diagnosis, nutritional status, and length of hospital stay were compared.
The study was conducted with 80 preterm infants, which consisted of continuous feeding (n=41) and intermittent bolus feeding (n=39). There was no significant difference in gender, gestational week, birth weight, height, and head circumference distribution of the babies between groups. The difference between the reach time to birth weight and maximum weight loss rates, parenteral feeding time, transition time to full enteral feeding, transition time to oral feeding, development of feeding intolerance, mechanical ventilation time, and hospitalization time in intensive care unit were not statistically significant. Necrotizing enterocolitis (NEC) Stage I and II developed in 34.1% of babies fed with continuous feeding model and 28.2% of babies fed intermittently; NEC was detected to start in 4.5±2.8 days in the continuous feeding group and in 2.8±5.2 days in the intermittent group. These differences were found to be insignificant between the two groups (p=0.634 and p=0.266, respectively).
There was no difference between growth parameters and discharge time of preterm babies who were applied continuous and intermittent bolus feeding model. Although there was no statistically significant difference on the development of NEC, it was determined that NEC developed earlier in the intermittent bolus feeding model.
本研究旨在确定间歇性推注喂养和持续喂养模式对极低出生体重儿早期生长及出院时间的影响。
本研究设计为一项前瞻性、随机对照研究。纳入我院1年内出生体重低于1500g的婴儿。样本量通过功效分析确定。婴儿根据出生体重随机分组，采用间歇性推注喂养和持续喂养模式。比较人口统计学特征、临床发现、诊断、营养状况及住院时间。
本研究纳入80例早产儿，分为持续喂养组（n = 41）和间歇性推注喂养组（n = 39）。两组婴儿在性别、孕周、出生体重、身高和头围分布上无显著差异。两组在达到出生体重的时间、最大体重减轻率、肠外营养时间、完全肠内营养过渡时间、经口喂养过渡时间、喂养不耐受的发生、机械通气时间及重症监护病房住院时间方面的差异无统计学意义。持续喂养模式组34.1%的婴儿和间歇性喂养模式组28.2%的婴儿发生坏死性小肠结肠炎（NEC）I期和II期；持续喂养组NEC在4.5±2.8天开始出现，间歇性喂养组在2.8±5.2天开始出现。两组间这些差异无统计学意义（分别为p = 0.634和p = 0.266）。
采用持续喂养和间歇性推注喂养模式的早产儿生长参数和出院时间无差异。虽然NEC的发生在统计学上无显著差异，但确定间歇性推注喂养模式下NEC出现得更早。
