Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Oxford Liver Unit, John Radcliffe Hospital, Oxford, United Kingdom.
Front Immunol. 2021 Apr 14;12:661196. doi: 10.3389/fimmu.2021.661196. eCollection 2021.
B cells form a branch of the adaptive immune system, essential for the body's immune defense against pathogens. B cell dysfunction has been implicated in the pathogenesis of immune mediated liver diseases including autoimmune hepatitis, IgG4-related hepatobiliary disease, primary biliary cholangitis and primary sclerosing cholangitis. B cells may initiate and maintain immune related liver diseases in several ways including the production of autoantibodies and the activation of T cells via antigen presentation or cytokine production. Here we comprehensively review current knowledge on B cell mechanisms in immune mediated liver diseases, exploring disease pathogenesis, B cell therapies, and novel treatment targets. We identify key areas where future research should focus to enable the development of targeted B cell therapies.
B 细胞构成了适应性免疫系统的一个分支，对于机体抵抗病原体的免疫防御至关重要。B 细胞功能障碍与多种免疫介导的肝脏疾病的发病机制相关，包括自身免疫性肝炎、IgG4 相关肝胆疾病、原发性胆汁性胆管炎和原发性硬化性胆管炎。B 细胞可通过多种方式启动和维持免疫相关的肝脏疾病，包括产生自身抗体以及通过抗原呈递或细胞因子产生激活 T 细胞。在此，我们全面综述了目前关于免疫介导的肝脏疾病中 B 细胞机制的相关知识，探讨了疾病发病机制、B 细胞治疗以及新的治疗靶点。我们确定了未来研究应重点关注的关键领域，以促进靶向 B 细胞治疗的发展。
